The Registry of Toxic Effects of Chemical Substances

p - Toluidine

RTECS #: XU3150000

CAS #: 106-49-0

UPDATE: November 2004 MW: 107.17 MF: C7H9N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Amino - 4 - methylbenzene
  2. 4 - Amino - 1 - methylbenzene
  3. 4 - Aminotoluen (Czech)
  4. p - Aminotoluene
  5. 4 - Aminotoluene
  6. Aniline, p - methyl -
  7. Benzenamine, 4 - methyl - (9CI)
  8. C.I. 37107
  9. C.I. Azoic Coupling Component 107
  10. Naphtol AS - KG
  11. Naphtol AS - KGLL
  1. RCRA waste number U353
  2. p - Methylaniline
  3. 4 - Methylaniline
  4. p - Methylbenzenamine
  5. 4 - Methylbenzenamine
  6. p - Toluidin (Czech)
  7. 4 - Toluidine
  8. p - Toluidyna (Polish)
  9. Tolylamine
  10. p - Tolylamine
  11. p - Toluidine (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe BIOFX* 31-4/1973
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,460,1986
skin
rabbit 		500 mg/24 hour severe BIOFX* 31-4/1973
skin
rabbit 		500 mg/24 hour mild 85JCAE -,460,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage intraperitoneal
mouse 		35 mg/kg ATSUDG 5,355,1982
DNA inhibition oral
mouse 		200 mg/kg MUREAV 46,305,1977
unscheduled DNA synthesis rat liver 100 µmol/L ENMUDM 5,803,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >640 mg/m3/1 hour N/R BIOFX* 31-4/1973
intraperitoneal
mouse 		lethal dose (50 percent kill): 50 mg/kg N/R NTIS** AD691-490
oral
wild bird 		lethal dose (50 percent kill): 42 mg/kg N/R TXAPA9 21,315,1972
oral
mouse 		lethal dose (50 percent kill): 330 mg/kg N/R GTPZAB 25(8),50,1981
oral
quail 		lethal dose (50 percent kill): 237 mg/kg N/R AECTCV 12,355,1983
oral
rat 		lethal dose (50 percent kill): 336 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		BCTKAG 17,51,1984
oral
rabbit 		lethal dose (50 percent kill): 270 mg/kg N/R VINIT* #4035-77
skin
rabbit 		lethal dose (50 percent kill): 890 mg/kg N/R BIOFX* 31-4/1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 4,560 mg/kg/30 day- intermittent Kidney, Ureter, and Bladder: Proteinuria

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VINIT* #4035-77


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (9 mg/m3), Skin, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Skin, Suspected Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (8.8 mg/m3), Skin, Carcinogen JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (9 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY Skin, Carcinogen, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (9 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 9 mg/m3, Skin, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-TOLUIDINE-air Carcinogen lowest feasible conc. (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0854;
Number of Industries 8;
Total Number of Facilities 508;
Number of Occupations 5;
Total Number of Employees Exposed 2,267
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0854;
Number of Industries 4;
Total Number of Facilities 206;
Number of Occupations 2;
Total Number of Employees Exposed 428;
Total Number of Female Employees Exposed 87


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; E coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #ID-73


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications.

Used as a chemical intermediate

NIOSH PROFILE (AMINES, PRIMARY AROMATIC), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Primary Irritant

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