The Registry of Toxic Effects of Chemical Substances

p - Toluenesulfonamide, N - chloro - , sodium salt

RTECS #: XT5616800

CAS #: 127-65-1

UPDATE: September 1998 MW: 228.66 MF: C7H8ClNO2S•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Acti - chlore
  2. Aktivin
  3. Anexol
  4. Benzenesulfonamide, N - chloro - 4 - methyl - , sodium salt (9CI)
  5. Berkendyl
  6. Chloralone
  7. Chloramine T
  8. Chlorasan
  9. Chloraseptine
  10. Chlorazan
  11. Chlorazene
  12. Chlorazone
  13. N - Chloro - 4 - methylbenzenesulfonamide sodium salt
  14. Chlorozone
  15. Chlorseptol
  16. Clorina
  17. Clorosan
  1. Desinfect
  2. Euclorina
  3. Gansil
  4. Multichlor
  5. Sodium chloramine T
  6. Sodium p - toluenesulfonylchloramide
  7. Sodium tosylchloramide
  8. Tampules
  9. Tochlorine
  10. Tolamine
  11. Gyneclorina
  12. Halamid
  13. Heliogen
  14. Kloramin
  15. Kloramine - T
  16. Tosylchloramide sodium


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 100 ppm/24 hour ARMCAH 21,409,1970
phage inhibition capacity Escherichia coli 255 µg/well MUREAV 260,349,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
rabbit 		lowest published lethal dose: 25 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Cyanosis 		JPETAB 14,259,1920
parenteral
frog 		lowest published lethal dose: 200 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression 		JPETAB 14,259,1920
parenteral
mouse 		lowest published lethal dose: 300 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory depression 		JPETAB 14,259,1920
subcutaneous
guinea pig 		lowest published lethal dose: 900 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle weakness 		JPETAB 14,259,1920


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
dog 		lowest published toxic dose: 186 mg/kg/16 week- intermittent Lung, Thorax, or Respiration: Emphysema NTIS** LMF-102


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83916;
Number of Industries 2;
Total Number of Facilities 93;
Number of Occupations 5;
Total Number of Employees Exposed 378
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83916;
Number of Industries 7;
Total Number of Facilities 190;
Number of Occupations 8;
Total Number of Employees Exposed 1,829;
Total Number of Female Employees Exposed 1,284


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ARMCAH Annual Review of Medicine. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.1- 1950-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Mutagen

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