The Registry of Toxic Effects of Chemical Substances

p - Toluenesulfonamide

RTECS #: XT5075000

CAS #: 70-55-3

UPDATE: September 2000 MW: 171.23 MF: C7H9NO2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Benzenesulfonamide, 4 - methyl - (9CI)
  2. 4 - Methylbenzenesulfonamide
  3. Plasticizer 15
  4. p - Toluenesulfanamide
  5. 4 - Toluenesulfanamide
  6. Toluene - p - sulphonamide
  7. Tolylsulfonamide
  1. p - Tosylamide
  2. Uniplex 173
  3. Toluene - 4 - sulfonamide
  4. p - Methylbenzenesulfonamide
  5. p - Toluenesulfonylamide
  6. p - Tolylsulfonamide
  7. Tosylamide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 40 µmol/plate (-enzymatic activation step) 45OHAA -,170,1980
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		2,500 µmol/plate 45OHAA -,170,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 250 mg/kg N/R NTIS** AD691-490
oral
wild bird 		lethal dose (50 percent kill): 75 mg/kg N/R TXAPA9 21,315,1972
subcutaneous
guinea pig 		lowest published lethal dose: 2 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle weakness 		JPETAB 14,259,1920


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1329;
Number of Industries 5;
Total Number of Facilities 195;
Number of Occupations 29;
Total Number of Employees Exposed 4,613
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1329;
Number of Industries 8;
Total Number of Facilities 304;
Number of Occupations 16;
Total Number of Employees Exposed 9,023;
Total Number of Female Employees Exposed 1,223


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate, in the manufacture of plastics, resins, rubber
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin, Springer-Verlag, 1980
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a chemical intermediate, in the manufacture of plastics, resins, rubber

RTECS Compound Description:
   Drug
   Mutagen

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