The Registry of Toxic Effects of Chemical Substances

Toluene, o - nitro -

RTECS #: XT3150000

CAS #: 88-72-2

UPDATE: May 2004 MW: 137.15 MF: C7H7NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1 - Methyl - 2 - nitrobenzene
  2. 2 - Methylnitrobenzene
  3. 2 - Nitrotoluene
  4. 2 - Nitrotoluol
  5. Benzene, 1 - methyl - 2 - nitro - (9CI)
  6. Nitrotoluene, ortho -
  1. ONT
  2. o - Methylnitrobenzene
  3. o - Nitrotoluene
  4. o - Nitrotoluene (ACGIH:OSHA)
  5. ortho - Nitrotoluol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct oral
rat 		150 mg/kg CBINA8 51,131,1984
unscheduled DNA synthesis oral
rat 		200 mg/kg CNREA8 43,2836,1983
unscheduled DNA synthesis rat liver 500 µg/L EMMUEG 26,147,1995
sister chromatid exchange hamster ovary 355 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 140 gm/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTPTR* NIH-93-3346
oral
rat 		lowest published toxic dose: 32,123 mg/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		NTPTR* NIH-93-3346
oral
rat 		lowest published toxic dose: 69,154 mg/kg (13 week prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders NTPTR* NIH-93-3346


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 109.5 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Vascular: Tumors

Gastrointestinal: Colon tumors 		TXCYAC 183,221,2003
oral
mouse 		lowest published toxic dose: 219 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors

Liver: Tumors 		TXCYAC 183,221,2003
oral
rat 		lowest published toxic dose: 54,600 mg/kg/26 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Reproductive: Other reproductive system tumors 		NTPTR* NIH-96-3936
oral
rat 		lowest published toxic dose: 27.4 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		TXCYAC 183,221,2003
oral
rat 		lowest published toxic dose: 87.6 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors 		TXCYAC 183,221,2003
oral
rat 		lowest published toxic dose: 10.1 gm/kg/12 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors 		TXCYAC 183,221,2003
oral
rat 		lowest published toxic dose: 25.2 gm/kg/12 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		TXCYAC 183,221,2003
oral
rat 		lowest published toxic dose: 45.6 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		TXCYAC 183,221,2003
oral
rat 		lowest published toxic dose: 182.5 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors 		TXCYAC 183,221,2003
oral
rat 		lowest published toxic dose: 32.12 gm/kg/13 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Other reproductive system tumors 		TOXID9 72,143,2003
oral
rat 		lowest published toxic dose: 26.57 gm/kg/13 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		TOXID9 72,143,2003


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 328 mg/m3 Brain and Coverings: Recordings from specific areas of CNS

Liver: Fatty liver degeneration

Blood: Methemoglobinemia- Carboxhemoglobinemia 		GTPZAB 22(7),52,1978
inhalation
rat 		lethal concentration (50 percent kill): 790 mg/m3 Brain and Coverings: Recordings from specific areas of CNS

Liver: Fatty liver degeneration

Blood: Methemoglobinemia- Carboxhemoglobinemia 		GTPZAB 22(7),52,1978
oral
mouse 		lethal dose (50 percent kill): 970 mg/kg N/R GTPZAB 25(8),50,1981
oral
rat 		lethal dose (50 percent kill): 891 mg/kg N/R NTIS** PB214-270
oral
rabbit 		lethal dose (50 percent kill): 1,750 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Liver: Fatty liver degeneration

Blood: Methemoglobinemia- Carboxhemoglobinemia 		GTPZAB 22(7),52,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 70,343 mg/kg/13 week- continuous Olfaction: Change in olfactory nerve

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTPTR* NIH-93-3346
oral
mouse 		lowest published toxic dose: 8,400 mg/kg/14 day- intermittent Blood: Changes in other cell count (unspecified) DCTODJ 17,359,1994
oral
mouse 		lowest published toxic dose: 6,825 mg/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 183,221,2003
oral
mouse 		lowest published toxic dose: 33,600 mg/kg/8 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 183,221,2003
oral
rat 		lowest published toxic dose: 32,123 mg/kg/13 week- continuous Liver: Changes in liver weight

Blood: Changes in platelet count

Related to Chronic Data: Changes in testicular weight 		NTPTR* NIH-93-3346
oral
rat 		lowest published toxic dose: 54,600 mg/kg/26 week- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		NTPTR* NIH-96-3936
oral
rat 		lowest published toxic dose: 3,937.5 mg/kg/15 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 183,221,2003
oral
rat 		lowest published toxic dose: 21,000 mg/kg/30 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 183,221,2003
oral
rat 		lowest published toxic dose: 36.4 gm/kg/26 week- intermittent Blood: Changes in spleen TOXID9 72,143,2003
oral
rat 		lowest published toxic dose: 924 mg/kg/3 week- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia TOXID9 72,143,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin) DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 65,409,1996
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 65,409,1996
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 65,409,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (30 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (30 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (30 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (30 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (11 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 2 ppm (11 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (11 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY Skin, Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (5.5 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN NGV 1 ppm (6 mg/m3), KTV 2 ppm (11 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND Skin, Carcinogen, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (29 mg/m3), short term exposure limit 10 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-NITROTOLUENE-air 10 hour time-weighted average 2 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81910;
Number of Industries 2;
Total Number of Facilities 20;
Number of Occupations 2;
Total Number of Employees Exposed 285


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of agriculture and rubber chemicals and in various dyes
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:mouse,rat
NTP Toxicity studies, RPT# TOX-23, October 2000
NTP Toxicity studies, RPT# TOX-44, October 2000
NTP Carcinogenesis studies; on test (two year studies), October 2000


REFERENCES:

CODEN
REFERENCE
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used in manufacture of agriculture and rubber chemicals and in various dyes

NIOSH PROFILE (NITROTOLUENES), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 57158-05-1
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