The Registry of Toxic Effects of Chemical Substances

Toluene, m - nitro -

RTECS #: XT2975000

CAS #: 99-08-1

UPDATE: November 2004 MW: 137.15 MF: C7H7NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Methyl - 3 - nitrobenzene
  2. 3 - Methylnitrobenzene
  3. 3 - Nitrotoluene
  4. 3 - Nitrotoluol
  5. Benzene, 1 - methyl - 3 - nitro - (9CI)
  6. MNT
  1. Nitrotoluene, meto -
  2. m - Methylnitrobenzene
  3. m - Nitrotoluene
  4. m - Nitrotoluene (ACGIH:OSHA)
  5. meta - Nitrotoluol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sister chromatid exchange hamster ovary 115 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 31,122 mg/kg (13 week prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders NTPTR* NIH-93-3346
oral
rat 		lowest published toxic dose: 60,151 mg/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		NTPTR* NIH-93-3346


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 425 mg/m3 Brain and Coverings: Recordings from specific areas of CNS

Liver: Fatty liver degeneration

Blood: Methemoglobinemia- Carboxhemoglobinemia 		GTPZAB 22(7),52,1978
inhalation
rat 		lethal concentration (50 percent kill): 693 mg/m3 Brain and Coverings: Recordings from specific areas of CNS

Liver: Fatty liver degeneration

Blood: Methemoglobinemia- Carboxhemoglobinemia 		GTPZAB 22(7),52,1978
oral
guinea pig 		lethal dose (50 percent kill): 3,600 mg/kg N/R CHABA8 73,91015e,1970
oral
mouse 		lethal dose (50 percent kill): 330 mg/kg N/R CHABA8 73,91015e,1970
oral
rat 		lethal dose (50 percent kill): 1,072 mg/kg N/R NTIS** PB214-270
oral
rabbit 		lethal dose (50 percent kill): 1,750 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Liver: Fatty liver degeneration

Blood: Methemoglobinemia- Carboxhemoglobinemia 		GTPZAB 22(7),52,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 30 mg/m3/4 hour/17 week- intermittent Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition 		GTPZAB 22(7),52,1978
oral
mouse 		lowest published toxic dose: 67,613 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in testicular weight 		NTPTR* NIH-93-3346
oral
mouse 		lowest published toxic dose: 5,600 mg/kg/14 day- intermittent Endocrine: Changes in thymus weight

Blood: Changes in other cell count (unspecified) 		DCTODJ 17,359,1994
oral
rat 		lowest published toxic dose: 31,122 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in platelet count

Related to Chronic Data: Changes in testicular weight 		NTPTR* NIH-93-3346


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin) DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 65,409,1996
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 65,409,1996
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 65,409,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (30 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (30 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (30 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (30 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (11 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 2 ppm (11 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (11 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (11 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 5 ppm (30 mg/m3), Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (5.5 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 3 mg/m3, MAC(short term exposure limit) 9 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 6 mg/m3, Skin, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (11 mg/m3), KZG- week 4 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (29 mg/m3), short term exposure limit 10 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO m-NITROTOLUENE-air 10 hour time-weighted average 2 ppm (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-23, October 2000


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHABA8 Chemical Abstracts. (Chemical Abstracts Service, Box 3012, Columbus, OH 43210) V.1- 1907-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

NIOSH PROFILE (NITROTOLUENES), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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