The Registry of Toxic Effects of Chemical Substances

Toluene, dinitro -

RTECS #: XT1300000

CAS #: 25321-14-6

UPDATE: November 2004 MW: 182.15 MF: C7H6N2O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Benzene, methyldinitro -
  2. Dinitrophenylmethane
  3. Dinitrotoluene
  1. Dinitrotoluene (ACGIH)
  2. Methyldinitrobenzene
  3. Toluene, ar,ar - dinitro -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis oral
rat 		35 mg/kg EMMUEG 14,155,1989
morphological transform oral
rat 		294 mg/kg/3 week- continuous CRNGDP 7,1797,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,050 mg/kg (7-20 day pregnant) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Effects on newborn: Delayed effects 		CIIT** DOCKET #10992,1982
oral
rat 		lowest published toxic dose: 196 mg/kg (7-20 day pregnant) Reproductive: Effects on newborn: Behavioral CIIT** DOCKET #10992,1982
oral
rat 		lowest published toxic dose: 2,100 mg/kg (7-20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FAATDF 5,948,1985
oral
rat 		lowest published toxic dose: 1,400 mg/kg (7-20 day pregnant) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) FAATDF 5,948,1985


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 12,775 mg/kg/1 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		PAACA3 24,91,1983


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lethal dose (50 percent kill): 1,300 mg/kg Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory stimulation 		GISAAA 42(10),17,1977
oral
mouse 		lethal dose (50 percent kill): 750 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		SRTCAC 36(1-4),10,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 4,550 µg/kg/26 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		GISAAA 42(10),17,1977
oral
rat 		lowest published toxic dose: 4,200 mg/kg/4 week- intermittent Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0546413


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg/m3 (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
TOLED5 127,321,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1.5 mg/m3 (skin) DTLVS* 3,93,1971
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 1.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA Skin, Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1.5 mg/m3, short term exposure limit 3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY Skin, Carcinogen, JAN1999
Occupational Exposure Limit - INDIA time-weighted average 1.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.15 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 5 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.15 ppm, KTV 0.3 ppm, Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND Carcinogen, Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 1.5 mg/m3, short term exposure limit 5 mg/m3, Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DINITROTOLUENE-air Carcinogen;
10 hour time-weighted average 1.5 mg/m3 (Sk) 		NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical and chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #44


REFERENCES:

CODEN
REFERENCE
CIIT** Chemical Industry Institute of Toxicology, Docket Reports. (POB 12137, Research Triangle Park, NC 27709)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used as an industrial chemical and chemical intermediate

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

 Click Here for Additional Information about RTECS