The Registry of Toxic Effects of Chemical Substances

Toluenediamine

RTECS #: XS9445000

CAS #: 25376-45-8

UPDATE: December 1997 MW: 122.19 MF: C7H10N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. NIOSH DOCUMENTATION AND SURVEILLANCE:
  4. STATUS IN FEDERAL AGENCIES:
  5. REFERENCES:

SYNONYMS:

  1. Benzenediamine, ar - methyl -
  2. Diaminotoluene
  3. RCRA waste number U221
  1. TDA 8020
  2. Methylphenylenediamine
  3. Tolylenediamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 240 mg/kg N/R ZHYGAM 29,395,1983
intraperitoneal
rat 		lethal dose (50 percent kill): 230 mg/kg N/R ZHYGAM 29,395,1983
intravenous
mouse 		lethal dose (50 percent kill): 90 mg/kg N/R ZHYGAM 29,395,1983
intravenous
rat 		lethal dose (50 percent kill): 350 mg/kg N/R ZHYGAM 29,395,1983
oral
mouse 		lethal dose (50 percent kill): 350 mg/kg N/R ZHYGAM 29,395,1983
oral
rat 		lethal dose (50 percent kill): 270 mg/kg N/R ZHYGAM 29,395,1983
skin
rat 		lethal dose (50 percent kill): 463 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Cyanosis

Kidney, Ureter, and Bladder: Other changes in urine composition 		NTIS** OTS0544321


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2689;
Number of Industries 1;
Total Number of Facilities 15;
Number of Occupations 1;
Total Number of Employees Exposed 29
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M2689;
Number of Industries 1;
Total Number of Facilities 4;
Number of Occupations 3;
Total Number of Employees Exposed 413


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the production of TOLUENEDIISOCYANATE, POLYOLS and a variety of other intermediates
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULE FEREAC 47,27009,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955-

Used in the production of TOLUENEDIISOCYANATE, POLYOLS and a variety of other intermediates

ALT CAS #: 26764-44-3
ALT CAS #: 30143-13-6
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