The Registry of Toxic Effects of Chemical Substances

Toluene, p - tert - butyl -

RTECS #: XS8400000

CAS #: 98-51-1

UPDATE: November 2004 MW: 148.27 MF: C11H16


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Methyl - 4 - tert - butylbenzene
  2. 4 - tert - Butyltoluene
  3. Benzene, 1 - methyl - 4 - (1,1 - dimethylethyl) - (9CI)
  4. TBT
  1. p - Methyl - tert - butylbenzene
  2. p - tert - Butyltoluene
  3. p - tert - Butyltoluene (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		5 ppm/2 hour N/R AMIHBC 9,227,1954
eye
rabbit 		100 mg N/R AMIHBC 9,227,1954
skin
rabbit 		500 mg/24 hour mild AMIHBC 9,227,1954


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 10 ppm/3 minute Gastrointestinal: Nausea or vomiting AMIHBC 9,227,1954
inhalation
human 		lowest published toxic concentration: 20 ppm/5 minute Eye: Conjunctiva irritation

Taste: Change in function

Gastrointestinal: Nausea or vomiting 		28ZRAQ -,156,1960
inhalation
mouse 		lethal concentration (50 percent kill): 248 ppm/4 hour Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Excitement 		AMIHBC 9,227,1954
inhalation
rat 		lethal concentration (50 percent kill): 165 ppm/8 hour Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		AMIHBC 9,227,1954
intraperitoneal
rat 		lethal dose (50 percent kill): 275 mg/kg N/R VCVGH* -,184,1990
intraperitoneal
rat 		lethal dose (16 percent kill): 188 mg/kg N/R VCVGH* -,184,1990
intraperitoneal
rat 		lethal dose (84 percent kill): 545 mg/kg N/R VCVGH* -,184,1990
oral
mouse 		lethal dose (50 percent kill): 778 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		AMIHBC 9,227,1954
oral
rat 		lethal dose (50 percent kill): 1,555 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		AMIHBC 9,227,1954
oral
rat 		lethal dose (50 percent kill): 1,600 mg/kg N/R VCVGH* -,184,1990
oral
rabbit 		lethal dose (50 percent kill): 1,728 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness 		AMIHBC 9,227,1954
skin
rabbit 		lethal dose (50 percent kill): 16,934 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature decrease 		AMIHBC 9,227,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 20 ppm/6 hour/14 day- intermittent Brain and Coverings: Recordings from specific areas of CNS PHTOEH 76,36,1995
inhalation
rat 		lowest published toxic concentration: 850 ppm/1 hour/5 day- intermittent Autonomic Nervous System: Other (direct) parasympathomimetic

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHBC 9,227,1954
inhalation
rat 		lowest published toxic concentration: 50 ppm/2 hour/26 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in leukocyte (WBC) count 		AMIHBC 9,227,1954
inhalation
rat 		lowest published toxic concentration: 25 ppm/2 hour/73 day- intermittent Liver: Changes in liver weight AMIHBC 9,227,1954
inhalation
rat 		lowest published toxic concentration: 50 ppm/7 hour/37 day- intermittent Liver: Changes in liver weight AMIHBC 9,227,1954
inhalation
rat 		lowest published toxic concentration: 20 ppm/4 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins 		PHTOEH 87,11,2000
inhalation
rat 		lowest published toxic concentration: 40 ppm/4 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS 		PHTOEH 87,11,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 ppm (60 mg/m3) DTLVS* 3,34,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 ppm (60 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 ppm (60 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 ppm (60 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 10 ppm (60 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (61 mg/m3), short term exposure limit 20 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 10 ppm (60 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (60 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (60 mg/m3), short term exposure limit 20 ppm (120 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 10 ppm (60 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 10 ppm (60 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (60 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 6.1 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (60 mg/m3), KZG- week 20 ppm (120 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 10 ppm (60 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-tert-BUTYLTOLUENE-air 10 hour time-weighted average 10 ppm;
short term exposure limit 20 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 14930;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 2;
Total Number of Employees Exposed 187


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501


REFERENCES:

CODEN
REFERENCE
28ZRAQ "Toxicology and Biochemistry of Aromatic Hydrocarbons," Gerarde, H., New York, Elsevier, 1960
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

NIOSH PROFILE (ARENES), SRI, 2/77

RTECS Compound Description:
   Human Data
   Primary Irritant

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