The Registry of Toxic Effects of Chemical Substances

Tin fluoride

RTECS #: XQ3450000

CAS #: 7783-47-3

UPDATE: May 2004 MW: 156.69 MF: F2Sn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Fluoristan
  2. Tin difluoride
  1. Stannous fluoride
  2. Tin bifluoride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 6 µmol/plate (-enzymatic activation step) MUREAV 90,91,1981
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		15 pph/24 hour FLUOA4 6,113,1973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 16,150 µg/kg N/R DZZEA7 34,484,1979
oral
mouse 		lethal dose (50 percent kill): 184 mg/kg N/R OYYAA2 2,411,1968
oral
rat 		lethal dose (50 percent kill): 360 mg/kg Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555162


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 392 mg/kg/10 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		TOLED5 7,463,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg(Sn)/m3 DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2.5 mg(F)/m3 DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 27,237,1982
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 27,237,1982
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,208,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2 mg(Sn)/m3 DTLVS* 3,257,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 2.5 mg(F)/m3, JAN1999
Occupational Exposure Limit - AUSTRIA MAK 2 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg(F)/m3, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 2.5 mg(F)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 2.5 mg(F)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 2.5 mg(F)/m3, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg(F)/m3, short term exposure limit 2 mg(F)/m3, JAN1993
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg(Sn)/m3, short term exposure limit 2 mg(Sn)/m3, Skin, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.6 mg(F)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg(HF)/m3, MAC(short term exposure limit) 3 mg(HF)/m3, JAN1999
Occupational Exposure Limit - POLAND time-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 2 mg(F)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1.8 ppm (1.5 mg(F)/m3), KZG- week 3.6 ppm (3.0 mg(F)/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2 mg(Sn)/m3, KZG- week 4 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - THAILAND time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2.5 mg(F)/m3, SEP2000
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 mg(Sn)/m3, short term exposure limit 4 mg(Sn)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as a human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as a human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUORIDES, INORGANIC-air 10 hour time-weighted average 2.5 mg(F)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 69735;
Number of Industries 2;
Total Number of Facilities 40;
Number of Occupations 3;
Total Number of Employees Exposed 79
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 69735;
Number of Industries 1;
Total Number of Facilities 146;
Number of Occupations 2;
Total Number of Employees Exposed 340;
Total Number of Female Employees Exposed 257


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in caries prophylactic
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag, Postfach 860420, D-8000 Munich 86, Fed. Rep. Ger.) V.1- 1946-
FLUOA4 Fluoride. (International Soc. for Fluoride Research, Inc., POB 692, Warren, MI 48090) V.3- 1970-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used in caries prophylactic

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen

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