The Registry of Toxic Effects of Chemical Substances

Tin (II) chloride (1:2)

RTECS #: XP8700000

CAS #: 7772-99-8

UPDATE: August 2004 MW: 189.59 MF: Cl2Sn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. C.I. 77864
  2. Dichlorotin
  3. Tin dichloride
  4. NCI - C02722
  1. Stannous chloride
  2. Stannous dichloride
  3. Uniston CR - HT 200


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 25 mg/L SCIEAS 236,933,1987
cytogenetic analysis intraperitoneal
mouse 		150 mg/kg EMMUEG 25,302,1995
cytogenetic analysis oral
rat 		0.125 µg/kg EMMUEG 39,69,2002
other mutation test systems Escherichia coli 150 nmol/tube LAMEDS 6,252,1986
phage inhibition capacity Escherichia coli 50 µg/well MUREAV 260,349,1991
sister chromatid exchange hamster ovary 25 mg/L SCIEAS 236,933,1987
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 6 mmol/L MUTAEX 1,21,1986
specific locus test oral
rat 		0.125 µg/kg EMMUEG 39,69,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratesticular
rat 		lowest published toxic dose: 15,167 µg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964
oral
rat 		lowest published toxic dose: 300 mg/kg (7-15 day pregnant) Reproductive: Other effects to embryo or fetus NEZAAQ 48,247,1993


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 44,100 mg/kg/105 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors 		NTIS** PB82-242553
oral
rat 		lowest published toxic dose: 73,500 mg/kg/105 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease 		NTIS** PB82-242553


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 65,598 µg/kg N/R COREAF 256,1043,1963
intraperitoneal
rat 		lethal dose (50 percent kill): 316 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		INJPD2 23,153,1991
intravenous
dog 		lowest published lethal dose: 20 mg/kg N/R HBAMAK 4,1420,1935
intravenous
mouse 		lethal dose (50 percent kill): 17,800 µg/kg N/R CSLNX* NX#02202
intravenous
rat 		lethal dose (50 percent kill): 17 mg/kg N/R USXXAM #5015462
oral
dog 		lowest published lethal dose: 500 mg/kg N/R HBAMAK 4,1420,1935
oral
guinea pig 		lowest published lethal dose: 60 mg/kg N/R FAONAU 50A,101,1972
oral
mouse 		lethal dose (50 percent kill): 250 mg/kg N/R FAONAU 50A,101,1972
oral
rat 		lethal dose (50 percent kill): 700 mg/kg N/R FOREAE 7,313,1942
oral
rabbit 		lethal dose (50 percent kill): 10 gm/kg N/R FAONAU 48A,75,1970
subcutaneous
dog 		lowest published lethal dose: 159 mg/kg N/R EQSSDX 1,1,1975
subcutaneous
guinea pig 		lowest published lethal dose: 400 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Nutritional and Gross Metabolic: Body temperature increase 		BMJOAE 2,217,1913
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 215 mg/kg N/R GISAAA 55(12),17,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 3 mg/m3/24 hour/5 week- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count 		GISAAA 55(12),17,1990
intramuscular
guinea pig 		lowest published toxic dose: 240 mg/kg/6 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field COREAF 243,2178,1956
intramuscular
mouse 		lowest published toxic dose: 360 mg/kg/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field COREAF 243,2178,1956
intramuscular
rabbit 		lowest published toxic dose: 240 mg/kg/6 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field COREAF 243,2178,1956
oral
mouse 		lowest published toxic dose: 328 gm/kg/13 week- continuous Gastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-231,1982
oral
rat 		lowest published toxic dose: 8,051 mg/kg/4 week- continuous Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Fe 		38MKAJ 2A,1946,1981
oral
rat 		lowest published toxic dose: 190 mg/kg/90 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Changes in: Ca 		TOLED5 9,207,1981
oral
rat 		lowest published toxic dose: 540 mg/kg/90 day- intermittent Liver: Other changes

Musculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		TXCYAC 16,267,1980
oral
rat 		lowest published toxic dose: 95,841 µg/kg/3 day- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Musculoskeletal: Other changes 		TOLED5 5,275,1980
oral
rat 		lowest published toxic dose: 6,300 mg/kg/4 week- continuous Behavioral: Food intake (animal)

Gastrointestinal: Changes in structure or function of exocrine pancreas

Blood: Changes in cell count (unspecified) 		VCVN1* -,408,1988
oral
rat 		lowest published toxic dose: 16,800 mg/kg/4 week- continuous Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		VCVN1* -,410,1988
oral
rat 		lowest published toxic dose: 14,000 mg/kg/4 week- continuous Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes 		VCVN1* -,410,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg(Sn)/m3 DTLVS* TLV/BEI,1999
TOXICOLOGY REVIEW
MUREAV 544,179,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2 mg(Sn)/m3 DTLVS* 3,257,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2 mg(Sn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 2 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 mg)Sn)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg(Sn)/m3, short term exposure limit 2 mg(Sn)/m3, Skin, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - POLAND time-weighted average 2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2 mg(Sn)/m3, KZG- week 4 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 2 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 mg(Sn)/m3, short term exposure limit 4 mg(Sn)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 mg(Sn)/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 mg(Sn)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 69730;
Number of Industries 69;
Total Number of Facilities 4,037;
Number of Occupations 43;
Total Number of Employees Exposed 50,592
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X8590;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 1;
Total Number of Employees Exposed 645;
Total Number of Female Employees Exposed 645
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 69730;
Number of Industries 49;
Total Number of Facilities 2,435;
Number of Occupations 40;
Total Number of Employees Exposed 43,253;
Total Number of Female Employees Exposed 15,296


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; TRP reversion
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a dye, pigment and printing ink
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);equivocal evidence:rat
NCI Carcinogenesis Studies (feed);no evidence:mouse


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
LAMEDS LARC Medical. (19 bis, rue d'Inkermann, 59000 Lille, France) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used as a dye, pigment and printing ink

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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