The Registry of Toxic Effects of Chemical Substances

Thiopyrophosphoric acid, tetraethyl ester

RTECS #: XN4375000

CAS #: 3689-24-5

UPDATE: November 2004 MW: 322.34 MF: C8H20O5P2S2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. ASP 47
  2. BAY - E - 393
  3. Bayer - E 393
  4. Bis - O,O - diethylphosphorothionic anhydride
  5. Bladafum
  6. Di (thiophosphoric) acid, tetraethyl ester
  7. Dithiodiphosphoric acid, tetraethyl ester
  8. Dithiofos
  9. Dithiophos
  10. Dithiopyrophosphate de tetraethyle (French)
  11. Dithiotep
  12. E393
  13. ENT 16,273
  14. Ethyl thiopyrophosphate ( (EtO) 2 (PS) 2O)
  15. Lethalaire G - 57
  16. O,O,O,O - Tetraaethyl - dithionopyrophosphat (German)
  17. O,O,O,O - Tetraethyl dithiopyrophosphate
  1. O,O,O,O - Tetraethyl - dithio - difosfaat (Dutch)
  2. O,O,O,O - Tetraetil - ditio - pirofosfato (Italian)
  3. Plantfume 103 smoke generator
  4. Pyrophosphorodithioic acid, O,O,O,O - tetraethyl ester
  5. Pyrophosphorodithioic acid, tetraethyl ester
  6. RCRA waste number P109
  7. Sulfotep
  8. Sulfotep (ACGIH:OSHA)
  9. Sulfotepp
  10. TEDP (OSHA)
  11. TEDTP
  12. Tetraethyl dithionopyrophosphate
  13. Tetraethyl dithiopyrophosphate
  14. Tetraethyldithiodifosfat (Czech)
  15. Thiodiphosphoric acid tetraethyl ester
  16. Thiotepp


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) EMMUEG 11(Suppl 12),1,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 40 mg/m3/4 hour Autonomic Nervous System: Other (direct) parasympathomimetic ARTODN 33,1,1974
inhalation
rat 		lethal concentration (50 percent kill): 38 mg/m3/4 hour Autonomic Nervous System: Other (direct) parasympathomimetic ARTODN 33,1,1974
intramuscular
mouse 		lethal dose (50 percent kill): 500 µg/kg N/R CJCHAG 34,1819,1956
intramuscular
rat 		lethal dose (50 percent kill): 55 µg/kg N/R CJCHAG 34,1819,1956
intraperitoneal
chicken 		lethal dose (50 percent kill): 25 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		ARTODN 33,1,1974
intraperitoneal
mouse 		lethal dose (50 percent kill): 940 µg/kg N/R CJCHAG 34,1819,1956
intraperitoneal
rat 		lethal dose (50 percent kill): 6,600 µg/kg Autonomic Nervous System: Other (direct) parasympathomimetic ARTODN 33,1,1974
intravenous
mouse 		lethal dose (50 percent kill): 300 µg/kg N/R CJCHAG 34,1819,1956
oral
wild bird 		lethal dose (50 percent kill): 100 mg/kg N/R TXAPA9 21,315,1972
oral
cat 		lethal dose (50 percent kill): 3 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic ARTODN 33,1,1974
oral
chicken 		lethal dose (50 percent kill): 25 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		ARTODN 33,1,1974
oral
dog 		lethal dose (50 percent kill): 5 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic ARTODN 33,1,1974
oral
mouse 		lethal dose (50 percent kill): 22 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic ARTODN 33,1,1974
oral
rat 		lethal dose (50 percent kill): 5 mg/kg N/R ARSIM* 20,24,1966
oral
rabbit 		lethal dose (50 percent kill): 25 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic ARTODN 33,1,1974
subcutaneous
mouse 		lethal dose (50 percent kill): 8 mg/kg N/R PAREAQ 11,636,1959
skin
rat 		lethal dose (50 percent kill): 65 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic ARTODN 33,1,1974
skin
rabbit 		lethal dose (50 percent kill): 20 mg/kg N/R WRPCA2 9,119,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 2,830 µg/m3/6 hour/12 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		ARTODN 33,1,1974
oral
rat 		lowest published toxic dose: 91 mg/kg/13 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		ARTODN 33,1,1974


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg/m3 (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
RREVAH 46,1,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,149,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg/m3 DTLVS* 3,244,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.2 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.2 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.2 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.2 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.015 ppm (0.2 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.015 ppm (0.2 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.015 ppm (0.2 mg/m3), Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.015 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.015 ppm (0.2 mg/m3), Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.2 mg/m3, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TEDP-air 10 hour time-weighted average 0.2 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82116;
Number of Industries 5;
Total Number of Facilities 674;
Number of Occupations 8;
Total Number of Employees Exposed 8,085;
Total Number of Female Employees Exposed 27


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8874
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705)
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CJCHAG Canadian Journal of Chemistry. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.29- 1951-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used in greenhouse fumigant formulations for control of aphids, spider mites, thrips, etc.

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

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