The Registry of Toxic Effects of Chemical Substances

Thiophene

RTECS #: XM7350000

CAS #: 110-02-1

UPDATE: September 2000 MW: 84.14 MF: C4H4S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. CP 34
  2. Thiacyclopentadiene
  3. Thiophen
  4. Divinylene sulfide
  5. Huile H50
  6. Huile HSO
  7. Thiaphene
  1. Thiofen (Czech)
  2. Thiofuran
  3. Thiofuram
  4. Thiofurfuran
  5. Thiole
  6. Thiotetrole
  7. USAF EK - 1860


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 9,500 mg/m3/2 hour N/R GTPZAB 10(2),57,1966
inhalation
rat 		lowest published lethal concentration: 2,000 ppm/6 hour N/R TOXID9 8,141,1988
intraperitoneal
mouse 		lethal dose (50 percent kill): 100 mg/kg N/R NTIS** AD277-689
oral
mouse 		lethal dose (50 percent kill): 420 mg/kg N/R GTPZAB 10(2),57,1966
oral
rat 		lethal dose (50 percent kill): 1,400 mg/kg N/R GTPZAB 10(2),57,1966
subcutaneous
rabbit 		lethal dose (50 percent kill): 830 mg/kg N/R 85JCAE -,1089,1986
skin
guinea pig 		lethal dose (50 percent kill): >20 mL/kg N/R NTIS** OTS0555960


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 1,010 mg/m3/6 hour/21 week- intermittent Liver: Liver function tests impaired

Endocrine: Evidence of thyroid hyperfunction 		GTPZAB 10(2),57,1966
inhalation
rat 		lowest published toxic concentration: 3 mg/m3/24 hour/80 day- continuous Behavioral: Muscle contraction or spasticity

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Endocrine: Other changes 		GISAAA 32(6),3,1967
inhalation
rat 		lowest published toxic concentration: 1,010 mg/m3/6 hour/21 week- intermittent Liver: Liver function tests impaired

Endocrine: Evidence of thyroid hyperfunction 		GTPZAB 10(2),57,1966
inhalation
rat 		lowest published toxic concentration: 1,600 ppm/6 hour/15 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555960
inhalation
rabbit 		lowest published toxic concentration: 1,010 mg/m3/6 hour/21 week- intermittent Liver: Liver function tests impaired

Endocrine: Evidence of thyroid hyperfunction 		GTPZAB 10(2),57,1966
oral
rat 		lowest published toxic dose: 9,500 mg/kg/19 day- intermittent Behavioral: Food intake (animal)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555960


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
ATORAI -,-,1948


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8861
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ATORAI A.P.I. Toxicological Review. (American Petroleum Institute, 2101 L St., NW, Washington, DC 20037)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

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