The Registry of Toxic Effects of Chemical Substances
Thiocyanic acid, potassium salt RTECS #: XL1925000
CAS #: 333-20-0
The Registry of Toxic Effects of Chemical Substances
Thiocyanic acid, potassium salt |
| UPDATE: February 2003 | MW: 97.18 | MF: CNS•K |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | domestic animal
lowest published toxic dose: 1,779 mg/kg (1-20 week pregnant)
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Reproductive: Specific developmental abnormalities: Endocrine system
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RJARAV 14,67,1976
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intramuscular | frog
lowest published lethal dose: 100 mg/kg
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N/R
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HBAMAK 4,1391,1935
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intramuscular | pigeon
lowest published lethal dose: 750 mg/kg
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N/R
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HBAMAK 4,1391,1935
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intraperitoneal | mouse
lethal dose (50 percent kill): 600 mg/kg
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N/R
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BJPCAL 4,1,1949
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intravenous | dog
lowest published lethal dose: 100 mg/kg
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N/R
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JAPMA8 29,152,1940
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intravenous | mouse
lethal dose (50 percent kill): 88,200 µg/kg
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Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea
JAPMA8 29,152,1940
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intravenous | rabbit
lowest published lethal dose: 150 mg/kg
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N/R
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HBAMAK 4,1391,1935
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oral | frog
lowest published lethal dose: 300 mg/kg
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N/R
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HBAMAK 4,1391,1935
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oral | guinea pig
lowest published lethal dose: 600 mg/kg
|
N/R
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JAPMA8 29,152,1940
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oral | human
lowest published lethal dose: 80 mg/kg
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Behavioral: Hallucinations, distorted perceptions | Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle weakness
JAMAAP 119,1177,1942
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oral | human
lowest published toxic dose: 428.6 mg/kg
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Behavioral: Toxic psychosis | Behavioral: Hallucinations, distorted perceptions Gastrointestinal: Gastritis
VCVN1* -,354,1988
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oral | man
lowest published toxic dose: 428 mg/kg
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Behavioral: Hallucinations, distorted perceptions | Behavioral: Toxic psychosis Gastrointestinal: Ulceration or bleeding from stomach
ATXKA8 23,66,1967
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oral | mouse
lethal dose (50 percent kill): 594 mg/kg
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Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea
JAPMA8 29,152,1940
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oral | mouse
lethal dose (50 percent kill): 590 mg/kg
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Lung, Thorax, or Respiration: Acute pulmonary edema | Liver: Other changes Behavioral: Tetany
VCVN1* -,353,1988
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oral | rat
lethal dose (50 percent kill): 854 mg/kg
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Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Dyspnea
JAPMA8 29,152,1940
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oral | rabbit
lowest published lethal dose: 500 mg/kg
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N/R
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HBAMAK 4,1391,1935
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subcutaneous | guinea pig
lowest published lethal dose: 150 mg/kg
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N/R
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HBAMAK 4,1391,1935
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subcutaneous | pigeon
lowest published lethal dose: 500 mg/kg
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N/R
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HBAMAK 4,1391,1935
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subcutaneous | rat
lowest published lethal dose: 1 gm/kg
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N/R
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JAPMA8 29,152,1940
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subcutaneous | rabbit
lowest published lethal dose: 550 mg/kg
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N/R
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HBAMAK 4,1391,1935
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unreported route | frog
lowest published lethal dose: 250 mg/kg
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N/R
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JAPMA8 29,152,1940
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
oral | dog
lowest published toxic dose: 600 mg/kg/22 day- intermittent
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPMA8 29,152,1940
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oral | rat
lowest published toxic dose: 47,040 mg/kg/50 week- continuous
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Kidney, Ureter, and Bladder: Other changes in urine composition | Endocrine: Changes in thyroid weight Blood: Other changes
JTEHD6 5,579,1979
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 60570; | Number of Industries 18; Total Number of Facilities 466; Number of Occupations 15; Total Number of Employees Exposed 3,959
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 60570 |
 ;Number of Industries 18; Total Number of Facilities 758; Number of Occupations 16; Total Number of Employees Exposed 17,270; Total Number of Female Employees Exposed 3,224 | ||||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
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EPA TSCA Section 8(b) CHEMICAL INVENTORY
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REFERENCES:
CODEN
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REFERENCE
ATXKA8
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Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher
information, see ARTODN.
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BJPCAL
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British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For
publisher information, see BJPCBM.
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HBAMAK
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"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
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JAMAAP
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JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL
60610) V.1- 1883-
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JAPMA8
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Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC)
V.29-49, 1940-60. For publisher information, see JPMSAE.
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JTEHD6
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Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW,
Washington, DC 20005) V.1- 1975/76-
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RJARAV
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Rhodesian Journal of Agricultural Research. (Salisbury, Rhodesia) V.1-17, 1963-79.
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VCVN1*
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"Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous
substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
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