The Registry of Toxic Effects of Chemical Substances

Thiocyanic acid, methylene ester

RTECS #: XL1560000

CAS #: 6317-18-6

UPDATE: August 2003 MW: 130.19 MF: C3H2N2S2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. CP 17879
  2. Methylendirhodanid (Czech)
  3. Methylendithiokyanat (Czech)
  1. Methylenebis (thiocyanate)
  2. Methylenedirhodanid (German)
  3. Methylene dithiocyanate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 260 mg/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTPTR* NIH-94-3381


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lethal dose (50 percent kill): 3,600 µg/kg N/R CSLNX* NX#03787
oral
rat 		lethal dose (50 percent kill): 55 mg/kg N/R DIMCAL 12,404,1971
subcutaneous
rabbit 		lowest published lethal dose: 20 mg/kg Behavioral: Convulsions or effect on seizure threshold

Vascular: BP lowering not characterized in autonomic section 		AEPPAE 150,257,1930
skin
rabbit 		lowest published lethal dose: 398 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Liver: Other changes 		NTIS** OTS0545751


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 120 mg/kg/2 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTPTR* NIH-94-3381
oral
mouse 		lowest published toxic dose: 520 mg/kg/13 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Gastrointestinal: Other changes

Liver: Other changes 		NTPTR* NIH-94-3381
oral
rat 		lowest published toxic dose: 240 mg/kg/2 week- intermittent Gastrointestinal: Necrotic changes

Endocrine: Changes in thymus weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NIH-94-3381
oral
rat 		lowest published toxic dose: 520 mg/kg/13 week- intermittent Olfaction: Other olfaction effects

Blood: Changes in erythrocyte (RBC) count

Biochemical: Metabolism (intermediary): Other proteins 		NTPTR* NIH-94-3381


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,192,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81675;
Number of Industries 8;
Total Number of Facilities 159;
Number of Occupations 3;
Total Number of Employees Exposed 1,670
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81675;
Number of Industries 26;
Total Number of Facilities 1,056;
Number of Occupations 24;
Total Number of Employees Exposed 24,231;
Total Number of Female Employees Exposed 995


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antimicrobial agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9235
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-32, October 2000


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DIMCAL Developments in Industrial Microbiology. (Soc. for Industrial Microbiology, 1401 Wilson Blvd., Arlington, VA 22209) V.1- 1960-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used as an antimicrobial agent

RTECS Compound Description:
   Tumorigen
   Reproductive Effector

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