The Registry of Toxic Effects of Chemical Substances

Thallium (I) sulfate (2:1)

RTECS #: XG6800000

CAS #: 7446-18-6

UPDATE: May 2004 MW: 504.80 MF: O4S•2Tl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Thallium sulfate
  2. Thallium (1) sulfate
  3. C.F.S.
  4. CSF - giftweizen
  5. Dithallium sulfate
  6. Dithallium (1+) sulfate
  7. Eccothal
  8. M7 - Giftkoerner
  1. Rattengiftkonserve
  2. RCRA waste number P115
  3. Sulfuric acid, dithallium (1+) salt (8CI,9CI)
  4. Sulfuric acid, thallium (1+) salt (1:2)
  5. Thallous sulfate
  6. Tharattin
  7. Zelio


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
human 		lowest published toxic dose: 15 mg/kg (210 day pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects HBPTO* 2,1381,2001
oral
rat 		lowest published toxic dose: 57 mg/kg (60 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) ENVRAL 40,531,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
rabbit 		lowest published lethal dose: 25 mg/kg N/R XATBAD 238,1,1931
oral
wild bird 		lowest published lethal dose: 37 mg/kg N/R JPETAB 48,478,1933
oral
cat 		lowest published lethal dose: 40 mg/kg N/R YKYUA6 28,329,1977
oral
duck 		lowest published lethal dose: 74 mg/kg N/R JPETAB 48,478,1933
oral
dog 		lowest published lethal dose: 16 mg/kg N/R YKYUA6 28,329,1977
oral
human 		lowest published lethal dose: 2,166 µg/kg N/R YKYUA6 28,329,1977
oral
man 		lowest published lethal dose: 3 mg/kg Eye: Other eye effects

Behavioral: Ataxia

Behavioral: Irritability 		85ECAN 2,101,1978
oral
man 		lowest published toxic dose: 7 µg/kg Behavioral: Convulsions or effect on seizure threshold

Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Other: Hair 		CTOXAO 17,133,1980
oral
man 		lowest published lethal dose: 14 mg/kg Peripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Somnolence (general depressed activity)

Cardiac: Change in rate 		JTSCDR 3,325,1978
oral
mouse 		lethal dose (50 percent kill): 23,500 µg/kg N/R GISAAA 29(2),23,1964
oral
mouse 		lethal dose (50 percent kill): 23.5 mg/kg Brain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli 		VCVN1* -,240,1988
oral
pig 		lowest published lethal dose: 2 mg/kg N/R YKYUA6 28,329,1977
oral
quail 		lowest published lethal dose: 29,640 µg/kg N/R JPETAB 48,478,1933
oral
rat 		lethal dose (50 percent kill): 16 mg/kg N/R YAKUD5 22,291,1980
oral
rat 		lowest published lethal dose: 24.7 mg/kg Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VHTODE 42,325,2000
oral
woman 		lowest published toxic dose: 175 mg/kg Peripheral Nerve and Sensation: Paresthesia

Kidney, Ureter, and Bladder: Other changes in urine composition

Skin and Appendages: Other: Hair 		JTCTDW 35,97,1997
subcutaneous
mouse 		lethal dose (50 percent kill): 26,600 µg/kg N/R MEPAAX 30,257,1979
subcutaneous
mouse 		lethal dose (50 percent kill): 57.7 mg/kg Brain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli 		VCVN1* -,240,1988
subcutaneous
rat 		lowest published lethal dose: 13 mg/kg N/R APTOA6 12,260,1956
skin
rat 		lethal dose (50 percent kill): 550 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair 		NNGADV 18,S209,1993
unreported route
rat 		lethal dose (50 percent kill): 15 mg/kg N/R YKYUA6 30,397,1979
unreported route
rabbit 		lethal dose (50 percent kill): 25 mg/kg N/R 85JFAN A390,1983


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 58,823 µg/kg/10 day- intermittent Gastrointestinal: Other changes

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JFALAX 5,15,1969
oral
rat 		lowest published toxic dose: 9 mg/kg/15 day- intermittent Behavioral: Somnolence (general depressed activity)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GISAAA 29(2),23,1964
oral
rat 		lowest published toxic dose: 336 mg/kg/240 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field HBPTO* 2,1381,2001
oral
rat 		lowest published toxic dose: 18.75 mg/kg/15 day- intermittent Behavioral: Somnolence (general depressed activity)

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVN1* -,242,1988
oral
rabbit 		lowest published toxic dose: 52.5 mg/kg/150 day- intermittent Gastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes primarily in glomeruli 		VCVN1* -,242,1988
subcutaneous
rabbit 		lowest published toxic dose: 52.5 mg/kg/150 day- intermittent Gastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes primarily in glomeruli 		VCVN1* -,242,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg(Tl)/m3 (skin) DTLVS* TLV/BEI,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg(Tl)/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg(Tl)/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg(Tl)/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg(Tl)/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Tl)/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 mg(Tl)/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(Tl)/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg(Tl)/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Tl)/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 mg(Tl)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg(Tl)/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg(Tl)/m3, MAC(short term exposure limit) 0.3 mg(Tl)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Tl)/m3, Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg(Tl)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 mg(Tl)/m3, Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(Tl)/m3, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 mg(Tl)/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 mg(Tl)/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a rat poison, ant bait and reagent in analytical chemistry
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
85ECAN "Metal Toxicity in Mammals, Vol. 2: Chemical Toxicity of Metals and Metalloids," Venugopal, B., and T.D. Luckey, New York, Plenum Press, 1978
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JFALAX Journal of the Faculty of Agriculture, Tottori University. (Tottori Univ., Faculty of Agriculture, Minami-4-101, Koyama-cho, Tottori 680, Japan) V.1- 1951-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
XATBAD Technical Bulletin - United States Department of Agriculture, Washington, D.C.).
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as a rat poison, ant bait and reagent in analytical chemistry

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector
   Human Data

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