The Registry of Toxic Effects of Chemical Substances

Thallium (I) carbonate (2:1)

RTECS #: XG4000000

CAS #: 6533-73-9

UPDATE: May 2004 MW: 468.75 MF: CO3•2Tl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Carbonic acid, dithallium (1+) salt
  2. Dithallium carbonate
  1. RCRA waste number U215
  2. Thallous carbonate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
rat 		100 ng/kg GTPZAB 24(4),54,1980
dominant lethal test oral
rat 		5 ng/kg MUREAV 124,163,1983
DNA damage mouse embryo 10 µmol/L MUREAV 124,163,1983
DNA damage rat embryo 1 µmol/L MUREAV 124,163,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 366 µg/kg (26 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) CHYCDW 21,141,1987
oral
mouse 		lowest published toxic dose: 36,740 µg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects WDZAEK 3,179,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 20.4 mg/m3/86 hour Behavioral: Euphoria

Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea 		GISAAA -,8,1993
oral
mouse 		lethal dose (50 percent kill): 21 mg/kg N/R HYSAAV 29(2),26,1964
oral
mouse 		lethal dose (50 percent kill): 21 mg/kg Brain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli 		VCVN1* -,240,1988
oral
rat 		lethal dose (50 percent kill): 21,800 µg/kg N/R WDZAEK 4,21,1990
oral
rat 		lethal dose (50 percent kill): 15 mg/kg Brain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli 		VCVN1* -,240,1988
subcutaneous
mouse 		lethal dose (50 percent kill): 27 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TPKVAL 2,94,1961
subcutaneous
mouse 		lethal dose (50 percent kill): 27 mg/kg Brain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli 		VCVN1* -,240,1988
subcutaneous
rat 		lowest published lethal dose: 18 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TPKVAL 2,94,1961
subcutaneous
rat 		lethal dose (50 percent kill): 18 mg/kg Brain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli 		VCVN1* -,240,1988
skin
rat 		lethal dose (50 percent kill): 117 mg/kg Olfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea 		GTPZAB 24(4),54,1980
unreported route
mouse 		lethal dose (50 percent kill): 20 pph N/R VCVN1* -,244,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 100 µg/m3/24 hour/38 day- continuous Blood: Other changes GISAAA 58(5),8,1993
inhalation
rat 		lowest published toxic concentration: 0.103 mg/m3/38 day- continuous Behavioral: Change in psychophysiological tests

Blood: Normocytic anemia

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) 		GISAAA -,8,1993
oral
mouse 		lowest published toxic dose: 2,400 µg/kg/5 day- intermittent Blood: Changes in spleen WDZAEK 4,78,1990
oral
rat 		lowest published toxic dose: 269 µg/kg/35 week- intermittent Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		GISAAA 45(9),11,1980
oral
rat 		lowest published toxic dose: 196 mg/kg/90 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		WDZAEK 4,21,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg(Tl)/m3 (skin) DTLVS* TLV/BEI,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg(Tl)/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg(Tl)/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg(Tl)/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg(Tl)/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Tl)/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 mg(Tl)/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(Tl)/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg(Tl)/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Tl)/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 mg(Tl)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg(Tl)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg(Tl)/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg(Tl)/m3, MAC(short term exposure limit) 0.3 mg(Tl)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg(Tl)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 mg(Tl)/m3, Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(Tl)/m3, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 mg(Tl)/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 mg(Tl)/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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