The Registry of Toxic Effects of Chemical Substances

2,2' - (2,5,8,11 - Tetraoxa - 1,12 - dodecane diyl) bisoxirane

RTECS #: XF0700000

CAS #: 1954-28-5

UPDATE: February 2005 MW: 262.34 MF: C12H22O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. REFERENCES:

SYNONYMS:

  1. Ayerst 62013
  2. Ethoglucid
  3. Ethoglucide
  4. Oxirane, 2,2' - (2,5,8,11 - tetraoxadodecane - 1,12 - diyl) bis - (9CI)
  5. 1,2 - Bis (2 - (2,3 - epoxypropoxy) ethoxy) ethane
  6. 1,2:15,16 - Diepoxy - 4,7,10,13 - tetraoxahexadecane
  7. Epodyl
  1. Etoglucid
  2. Etoglucide
  3. ICI - 32865
  4. 2,2' - (2,5,8,11 - Tetraoxadodecane - 1,12 - diyl) bisoxirane
  5. 4,7,10,13 - Tetraoxahexadecane, 1,2:15,16 - diepoxy - (8CI)
  6. Triethylene glycol diglycidyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		10 mg/24 hour open irritation test mild AIHAAP 23,95,1962


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 300 µg/plate (+enzymatic activation step) MUREAV 111,99,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 3,800 mg/kg/4 week Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		JNCIAM 36,915,1966


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published lethal dose: 700 mg/kg N/R IMEMDT 11,209,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 11,209,1976
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 11,209,1976
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1539,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 71,1539,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1539,1999
TOXICOLOGY REVIEW
CREOH* 47,109,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CREOH* Critical Reviews in Oncology/Hematology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1983-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

Used as a chemical intermediate for polymer and fiber modification, and as a drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Primary Irritant

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