The Registry of Toxic Effects of Chemical Substances

Terephthalic acid

RTECS #: WZ0875000

CAS #: 100-21-0

UPDATE: November 2004 MW: 166.14 MF: C8H6O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Acide terephtalique (French)
  2. p - Benzenedicarboxylic acid
  3. 1,4 - Benzenedicarboxylic acid
  4. p - Carboxybenzoic acid
  5. p - Dicarboxybenzoic acid
  1. Kyselina tereftalova (Czech)
  2. TA - 33MP
  3. Terephthalic acid (ACGIH)
  4. WR 16262


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 85JCAE -,317,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,430 mg/kg N/R CPBTAL 16,1655,1968
intravenous
dog 		lowest published lethal dose: 767 mg/kg N/R TXAPA9 18,469,1971
oral
mouse 		lethal dose (50 percent kill): 3,200 mg/kg N/R KODAK* 21MAY1971
oral
rat 		lethal dose (50 percent kill): >6,400 mg/kg N/R KODAK* 21MAY1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 5 mg/m3/2 hour/26 week- intermittent Vascular: BP lowering not characterized in autonomic section

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TPKVAL 7,91,1965
oral
mouse 		lowest published toxic dose: 5,964 mg/kg/7 day- intermittent Liver: Liver function tests impaired CPBTAL 16,1655,1968
oral
rat 		lowest published toxic dose: 364 gm/kg/1 year- continuous Eye: Other eye effects

Liver: Changes in liver weight 		NTIS** OTS0570926
oral
rat 		lowest published toxic dose: 104 gm/kg/2 year- continuous Brain and Coverings: Changes in brain weight

Cardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTIS** OTS0543783
oral
rat 		lowest published toxic dose: 108 gm/kg/90 day- intermittent Kidney, Ureter, and Bladder: Other changes NTIS** OTS0546333


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
BPCT** -,183,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82013;
Number of Industries 26;
Total Number of Facilities 1,682;
Number of Occupations 42;
Total Number of Employees Exposed 22,732
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82013;
Number of Industries 8;
Total Number of Facilities 282;
Number of Occupations 16;
Total Number of Employees Exposed 6,456;
Total Number of Female Employees Exposed 2,563


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of POLYETHYLENE TEREPHTHALATE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
BPCT** Progress Report from the Environmental Protection Agency to NIOSH on Benzenepolycarboxylates, 1974
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in production of POLYETHYLENE TEREPHTHALATE

Top 50 chemical production: 5.64 billions lbs in 1992, 7.64 billions in 1991

NIOSH PROFILE (TEREPHTHALIC ACID), SRC, 12/79

RTECS Compound Description:
   Drug
   Mutagen
   Primary Irritant

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