The Registry of Toxic Effects of Chemical Substances

Terephthalic acid, dimethyl ester

RTECS #: WZ1225000

CAS #: 120-61-6


UPDATE: November 2004 MW: 194.20 MF: C10H10O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Di - Me terephthalate
  2. Dimethyl 1,4 - benzenedicarboxylate
  3. Dimethylester kyseliny tereftalove (Czech)
  4. Dimethyl p - phthalate
  5. Dimethyl terephthalate
  6. 1,4 - Benzenedicarboxylic acid, dimethyl ester (9CI)
  1. DMT
  2. Methyl 4 - carbomethoxybenzoate
  3. Methyl p - (methoxycarbonyl) benzoate
  4. NCI - C50055
  5. Terephthalic acid methyl ester


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg/24 hour mild 85JCAE -,386,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
micronucleus test intraperitoneal
mouse
200 µmol/kg MUREAV 204,703,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lethal dose (50 percent kill): 3,900 mg/kg Behavioral: Muscle weakness AIHAAP 34,455,1973
oral
rat
lethal dose (50 percent kill): >3,200 mg/kg N/R 14CYAT 2,1906,1963
skin
guinea pig
lethal dose (50 percent kill): >5 gm/kg N/R 14CYAT 2,1906,1963


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1 mg/m3/2 hour/22 week- intermittent Olfaction: Other olfaction effects

Vascular: BP lowering not characterized in autonomic section

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 5,107,1963
oral
rat
lowest published toxic dose: 57,600 mg/kg/14 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain AIHAAP 34,455,1973


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
BPCT** -,183,1974
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83502;
Number of Industries 5;
Total Number of Facilities 58;
Number of Occupations 7;
Total Number of Employees Exposed 993
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83502;
Number of Industries 3;
Total Number of Facilities 104;
Number of Occupations 3;
Total Number of Employees Exposed 2,467;
Total Number of Female Employees Exposed 204


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of POLYETHYLENE TEREPHTHALATE
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);equivocal evidence:mouse NCITR* NCI-TR-121,1979
NCI Carcinogenesis Bioassay (feed);no evidence:rat NCITR* NCI-TR-121,1979


REFERENCES:

CODEN
REFERENCE

14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BPCT** Progress Report from the Environmental Protection Agency to NIOSH on Benzenepolycarboxylates, 1974
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used in production of POLYETHYLENE TEREPHTHALATE

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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