The Registry of Toxic Effects of Chemical Substances
Terephthalic acid, dimethyl ester |
UPDATE: November 2004 | MW: 194.20 | MF: C10H10O4 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
500 mg/24 hour
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mild
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85JCAE -,386,1986
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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micronucleus test
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intraperitoneal | mouse
200 µmol/kg
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MUREAV 204,703,1988
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intraperitoneal | rat
lethal dose (50 percent kill): 3,900 mg/kg
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Behavioral: Muscle weakness
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AIHAAP 34,455,1973
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oral | rat
lethal dose (50 percent kill): >3,200 mg/kg
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N/R
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14CYAT 2,1906,1963
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skin | guinea pig
lethal dose (50 percent kill): >5 gm/kg
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N/R
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14CYAT 2,1906,1963
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | rat
lowest published toxic concentration: 1 mg/m3/2 hour/22 week- intermittent
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Olfaction: Other olfaction effects | Vascular: BP lowering not characterized in autonomic section Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 5,107,1963
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oral | rat
lowest published toxic dose: 57,600 mg/kg/14 week- continuous
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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AIHAAP 34,455,1973
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
TOXICOLOGY REVIEW
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BPCT** -,183,1974
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TOXICOLOGY REVIEW
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MUREAV 543,201,2003
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Occupational Exposure Limit - RUSSIA
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short term exposure limit 0.1 mg/m3, JAN1993
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 83502; | Number of Industries 5; Total Number of Facilities 58; Number of Occupations 7; Total Number of Employees Exposed 993
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 83502; |
Number of Industries 3; Total Number of Facilities 104; Number of Occupations 3; Total Number of Employees Exposed 2,467; Total Number of Female Employees Exposed 204 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Cell transform.-SA7/SHE
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EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used in production of POLYETHYLENE TEREPHTHALATE
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On EPA IRIS database
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NCI Carcinogenesis Bioassay (feed);equivocal evidence:mouse
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NCITR* NCI-TR-121,1979
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NCI Carcinogenesis Bioassay (feed);no evidence:rat
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NCITR* NCI-TR-121,1979
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REFERENCES:
CODEN
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REFERENCE
14CYAT
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"Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons,
Inc., 1958-63
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85JCAE
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"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
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AIHAAP
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American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH
44311) V.19- 1958-
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BPCT**
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Progress Report from the Environmental Protection Agency to NIOSH on Benzenepolycarboxylates,
1974
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MUREAV
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Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NCITR*
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National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205.
For publisher information, see NTPTR*.
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TPKVAL
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Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial
Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow,
USSR) No.1- 1961-
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