RTECS:WT5075000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

Sulfuryl fluoride

RTECS #: WT5075000

CAS #: 2699-79-8

UPDATE: November 2004 MW: 102.06 MF: F₂O₂S

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Sulfuric oxyfluoride

Sulfuryl difluoride

Fluorure de sulfuryle (French)

Sulfuryl fluoride (ACGIH:OSHA)

Vikane

Vikane fumigant

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 225 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system FAATDF 13,79,1989
inhalation
rabbit lowest published toxic concentration: 225 ppm/6 hour (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system FAATDF 13,79,1989

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mouse lowest published lethal concentration: 1,200 ppm/1 hour Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis AMPMAR 34,581,1973
inhalation
mouse lethal concentration (50 percent kill): 642 ppm/4 hour N/R FEREAC 67,7158,2002
inhalation
rat lethal concentration (50 percent kill): 991 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Cyanosis FAATDF 7,664,1986
inhalation
rabbit lowest published lethal concentration: 5,000 ppm/1 hour Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis AMPMAR 34,581,1973
oral
guinea pig lethal dose (50 percent kill): 100 mg/kg N/R DOWCC*
oral
rat lethal dose (50 percent kill): 100 mg/kg N/R 85ARAE 3,15,1976/1977

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mouse lowest published toxic concentration: 80 ppm/6 hour/78 week- intermittent Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOXID9 14,394,1994
inhalation
rat lowest published toxic concentration: 600 ppm/6 hour/2 week- intermittent Kidney, Ureter, and Bladder: Proteinuria

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain FAATDF 12,540,1989
inhalation
rat lowest published toxic concentration: 300 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition FAATDF 12,540,1989
inhalation
rat lowest published toxic concentration: 80 ppm/6 hour/2 year- intermittent Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOXID9 14,394,1994
inhalation
rabbit lowest published toxic concentration: 337 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Changes in: Other metals FAATDF 12,540,1989

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 10 ppm DTLVS* TLV/BEI,2003

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,150,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (20 mg/m³) DTLVS* 3,241,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (20 mg/m³) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (20 mg/m³) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (20 mg/m³) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (20 mg/m³) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (20 mg/m³), short term exposure limit 10 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 2.5 mg(F)/m³, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (21 mg/m³), short term exposure limit 10 ppm (42 mg/m³), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (20 mg/m³), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (20 mg/m³), short term exposure limit 10 ppm (40 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (20 mg/m³), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (20 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 20 mg/m³, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg(HF)/m³, MAC(short term exposure limit) 3 mg(HF)/m³, JAN1999
Occupational Exposure Limit - SWEDEN NGV 2 mg(F)/m³, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (20 mg/m³), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (21 mg/m³), short term exposure limit 10 ppm (42 mg/m³), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 10 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 10 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SULFURYL FLUORIDE-air 10 hour time-weighted average 5 ppm;
short term exposure limit 10 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 70960;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 3;
Total Number of Employees Exposed 357
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 70960;
Number of Industries 2;
Total Number of Facilities 350;
Number of Occupations 3;
Total Number of Employees Exposed 5,136

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a fumigant
NIOSH Analytical Method, 1994: Sulfuryl fluoride, 6012

REFERENCES:
CODEN
REFERENCE

85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as a fumigant

NIOSH PROFILE (FUMIGANTS), SRC, 10/77

RTECS Compound Description:
Agricultural Chemical
Reproductive Effector

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