The Registry of Toxic Effects of Chemical Substances

Sulfone, p - chlorophenyl 2,4,5 - trichlorophenyl

RTECS #: WR5850000

CAS #: 116-29-0

UPDATE: February 2005 MW: 356.04 MF: C12H6Cl4O2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. REFERENCES:

SYNONYMS:

  1. Akaritox
  2. Aredion
  3. p - Chlorophenyl 2,4,5 - trichlorophenyl sulfone
  4. 4 - Chlorophenyl 2,4,5 - trichlorophenyl sulfone
  5. p - Chlorophenyl 2,4,5 - trichlorophenyl sulphone
  6. Benzene, 1,2,4 - trichloro - 5 - ( (4 - chlorophenyl) sulfonyl) -
  7. Duphar
  8. ENT 23,737
  9. FMC 5488
  10. Mition
  11. NIA 5488
  12. Polacaritox
  13. Roztozol
  14. Sulfone, 2,4,4',5 - tetrachlorodiphenyl
  1. Tedion
  2. Tedion V - 18
  3. Tetrafidon
  4. Tetradichlone
  5. Tetradifon
  6. Tetradiphon
  7. 2,4,4',5 - Tetrachloor - difenyl - sulfon (Dutch)
  8. 2,4,4',5 - Tetrachlor - diphenyl - sulfon (German)
  9. 3,4,6,4' - Tetrachlor - diphenylsulfon (German)
  10. 2,4,4',5 - Tetrachlorodiphenyl sulfone
  11. 2,4,5,4' - Tetrachlorodiphenyl sulfone
  12. 2,4,5,4' - Tetrachlorodiphenylsulphone
  13. 2,4,4',5 - Tetracloro - difenil - solfone (Italian)
  14. V - 18


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sister chromatid exchange human lymphocyte 100 µmol/L ARTODN 52,221,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 1,953 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lethal dose (50 percent kill): 2 gm/kg N/R SPEADM 78-1,55,1978
oral
rat 		lethal dose (50 percent kill): 566 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit 		lethal dose (50 percent kill): 10 gm/kg N/R 28ZEAL 5,220,1976
unreported route
rat 		lethal dose (50 percent kill): 5 gm/kg N/R RREVAH 36,240,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 5,040 mg/kg/12 week- continuous Liver: Other changes

Liver: Changes in liver weight

Endocrine: Changes in thyroid weight 		TXCYAC 1,113,1973


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 562,77,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,212,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as an ascarid ovocide on deciduous fruits, citrus, cotton and other crops

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector

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