The Registry of Toxic Effects of Chemical Substances
Succinonitrile, tetramethyl - RTECS #: WN4025000
CAS #: 3333-52-6
The Registry of Toxic Effects of Chemical Substances
Succinonitrile, tetramethyl - |
| UPDATE: November 2004 | MW: 136.22 | MF: C8H12N2 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intraperitoneal | hamster
lowest published toxic dose: 9,944 µg/kg (8 day pregnant)
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Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
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FAATDF 3,41,1983
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | cat
lethal concentration : >281 mg/m3/2 hour
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N/R
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ATXKA8 16,367,1957
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inhalation | mouse
lowest published lethal concentration: 125 mg/m3/2 hour
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Behavioral: Convulsions or effect on seizure threshold
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ATXKA8 16,367,1957
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inhalation | rat
lowest published lethal concentration: 60 ppm/2 hour
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N/R
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FEPRA7 8,205,1949
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intraperitoneal | mouse
lethal dose (50 percent kill): 17,710 µg/kg
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Behavioral: Convulsions or effect on seizure threshold
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JPETAB 223,635,1982
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intraperitoneal | rat
lethal dose (50 percent kill): 17,500 µg/kg
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N/R
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ATXKA8 16,367,1957
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intravenous | mouse
lethal dose (50 percent kill): 18 mg/kg
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N/R
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CSLNX* NX#00002
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intravenous | rabbit
lethal dose (50 percent kill): 20 mg/kg
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N/R
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FEPRA7 8,205,1949
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oral | guinea pig
lethal dose (50 percent kill): 17,500 µg/kg
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N/R
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ATXKA8 16,367,1957
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oral | rat
lethal dose (50 percent kill): 27 mg/kg
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Behavioral: Somnolence (general depressed activity) | Behavioral: Tremor Lung, Thorax, or Respiration: Pulmonary emboli
NTIS** OTS0555206
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oral | rabbit
lowest published lethal dose: 25 mg/kg
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Behavioral: Convulsions or effect on seizure threshold
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ATXKA8 16,367,1957
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subcutaneous | dog
lowest published lethal dose: 20 mg/kg
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N/R
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FEPRA7 8,205,1949
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subcutaneous | guinea pig
lethal dose (50 percent kill): 23 mg/kg
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N/R
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FEPRA7 8,205,1949
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subcutaneous | mouse
lowest published lethal dose: 30 mg/kg
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Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Other changes
ATXKA8 16,367,1957
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subcutaneous | rat
lethal dose (50 percent kill): 30 mg/kg
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N/R
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FEPRA7 8,205,1949
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subcutaneous | rabbit
lowest published lethal dose: 30 mg/kg
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Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Other changes
ATXKA8 16,367,1957
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skin | rabbit
lowest published lethal dose: 79,400 µg/kg
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Behavioral: Somnolence (general depressed activity) | Behavioral: Muscle weakness Lung, Thorax, or Respiration: Pulmonary emboli
NTIS** OTS0555206
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | rat
lowest published toxic dose: 270 mg/kg/90 day- continuous
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Liver: Changes in liver weight | Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 7,41,1986
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 0.5 ppm (skin)
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DTLVS* TLV/BEI,2003
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air
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time-weighted average 0.5 ppm (3 mg/m3) (skin)
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DTLVS* 3,254,1971
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
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8 hour time-weighted average 0.5 ppm (3 mg/m3) (skin)
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CFRGBR 29,1910.1000,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
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8 hour time-weighted average 0.5 ppm (3 mg/m3) (skin)
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CFRGBR 29,1926.55,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
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8 hour time-weighted average 0.5 ppm (3 mg/m3) (skin)
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CFRGBR 29,1915.1000,1993
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)
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8 hour time-weighted average 0.5 ppm (3 mg/m3) (skin)
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CFRGBR 41,50-204.50,1994
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Occupational Exposure Limit - AUSTRALIA
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time-weighted average 0.5 ppm (3 mg/m3), Skin, JAN1993
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Occupational Exposure Limit - AUSTRIA
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MAK 0.5 ppm (3 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - BELGIUM
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time-weighted average 0.5 ppm (28 mg/m3), Skin, JAN1993
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Occupational Exposure Limit - DENMARK
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time-weighted average 0.5 ppm (3 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - FINLAND
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time-weighted average 0.5 ppm (3 mg/m3), short term exposure limit 1.5 ppm (8.4 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - FRANCE
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VME 0.5 ppm (3 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - GERMANY
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MAK 0.5 ppm (3 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 3 mg/m3, Skin, 2003
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Occupational Exposure Limit - THE PHILIPPINES
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time-weighted average 0.5 ppm (3 mg/m3), Skin, JAN1993
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Occupational Exposure Limit - SWITZERLAND
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MAK- week 0.3 ppm (5 mg/m3), KZG- week 2 ppm, Skin, JAN1999
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Occupational Exposure Limit - UNITED KINGDOM
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time-weighted average 0.5 ppm (2.8 mg/m3), short term exposure limit 2 ppm, Skin, SEP2000
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Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | time-weighted average 0.5 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
time-weighted average 0.5 ppm (skin) | |||||||||||||||
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRAMETHYL SUCCINONITRILE-air
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10 hour time-weighted average 0.5 ppm (Sk)
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NIOSH* DHHS #92-100,1992
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
ATXKA8
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Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher
information, see ARTODN.
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CFRGBR
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Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402)
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CSLNX*
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U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange
Chemicals. (Aberdeen Proving Ground, MD 21010)
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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FAATDF
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Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1-40, 1981-97. For publisher information, see TOSCF2
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FEPRA7
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Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda,
MD) V.1-46, 1942-87.
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JPETAB
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Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E.
Preston St., Baltimore, MD 21202) V.1- 1909/10-
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NIOSH*
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National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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