The Registry of Toxic Effects of Chemical Substances
Succinonitrile |
UPDATE: October 1997 | MW: 80.10 | MF: C4H4N2 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
N/R | N/R | N/R | N/R |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal hamster | lowest published toxic dose: 365 mg/kg (8 day pregnant) |
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Central nervous system | FAATDF 3,41,1983 |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published lethal concentration: 730 mg/m3/4 hour |
Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Acute pulmonary edema | NTIS** OTS0570875 |
intraperitoneal mouse | lethal dose (50 percent kill): 63,110 痢/kg | Kidney, Ureter, and Bladder: Other changes in urine composition | BCPCA6 27,1135,1978 |
oral mouse | lethal dose (50 percent kill): 129 mg/kg | N/R | ARTODN 57,88,1985 |
oral rat | lethal dose (50 percent kill): 450 mg/kg | N/R | 38MKAJ 2C,4879,1982 |
subcutaneous dog | lowest published lethal dose: 150 mg/kg |
Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Nausea or vomiting | AIPTAK 3,77,1897 |
subcutaneous frog | lowest published lethal dose: 1 gm/kg | N/R | AIPTAK 3,77,1897 |
subcutaneous pigeon | lowest published lethal dose: 2,200 mg/kg |
Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Nausea or vomiting | AIPTAK 3,77,1897 |
subcutaneous rabbit | lowest published lethal dose: 36 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change | AIPTAK 3,77,1897 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
N/R | N/R | N/R |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
N/R | N/R | N/R |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SUCCINONITRILE-air | 10 hour time-weighted average 6 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: X5846![]() Number of Industries 1; Total Number of Facilities 44; Number of Occupations 3; Total Number of Employees Exposed 1,440 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as an antidepressive agent in some European countries | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
REFERENCES: | |
CODEN |
REFERENCE |
38MKAJ | "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. |
AIPTAK | Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- |
ARTODN | Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- |
BCPCA6 | Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- |
FAATDF | Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |