The Registry of Toxic Effects of Chemical Substances

Succinic acid, mercapto - , diethyl ester, S - ester with O,O - dimethylphosphorodithioate

RTECS #: WM8400000

CAS #: 121-75-5

UPDATE: February 2005 MW: 330.38 MF: C10H19O6PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. ( (Dimethoxyphosphinothioyl) thio) butanedioic acid diethyl ester
  2. 1,2 - Di (ethoxycarbonyl) ethyl O,O - dimethyl phosphorodithioate
  3. American cyanamid 4,049
  4. Carbethoxy malathion
  5. Carbetovur
  6. Carbetox
  7. Carbofos
  8. Carbophos
  9. Chemathion
  10. Cimexan
  11. Siptox I
  12. Sumitox
  13. TAK
  14. TM - 4049
  15. Vegfru malatox
  16. Vetiol
  17. Zithiol
  18. Compound 4049
  19. Cythion
  20. Detmol MA
  21. Detmol MA 96%
  22. Dicarboethoxyethyl O,O - dimethyl phosphorodithioate
  23. Diethyl ( (dimethoxyphosphinothioyl) thio) butanedioate
  24. Diethyl (dimethoxyphosphinothioylthio) succinate
  25. Diethyl mercaptosuccinate S - ester with O,O - dimethylphosphorodithioate
  26. Diethyl mercaptosuccinate, O,O - dimethyl dithiophosphate, S - ester
  27. Diethyl mercaptosuccinate, O,O - dimethyl phosphorodithioate
  28. Diethyl mercaptosuccinate, O,O - dimethyl thiophosphate
  29. Diethyl mercaptosuccinic acid O,O - dimethyl phosphorodithioate
  30. Dithiophosphate de O,O - dimethyle et de S - (1,2 - dicarboethoxyethyle) (French)
  31. EL 4049
  32. ENT 17,034
  33. Emmatos
  34. Emmatos Extra
  35. Ethiolacar
  36. Etiol
  37. Experimental insecticide 4049
  38. Extermathion
  39. Forthion
  40. Fosfothion
  41. Fosfotion
  42. Fosfotion 550
  43. Fyfanon
  44. Hilthion
  45. Hilthion 25WDP
  46. Insecticide No. 4049
  47. Karbofos
  48. Kop - thion
  49. Kypfos
  50. Latka 4049 (Czech)
  51. Malacide
  52. Malafor
  53. Malagran
  1. Malakill
  2. Malamar
  3. Malamar 50
  4. Malaphele
  5. Malaphos
  6. Malasol
  7. Malaspray
  8. Malathion
  9. Malathion (ACGIH:OSHA)
  10. Malathion E50
  11. Malathion LV concentrate
  12. Malathion ULV concentrate
  13. Malathon
  14. Malathyl LV concentrate & ULV concentrate
  15. Malation (Polish)
  16. Malatol
  17. Malatox
  18. Maldison
  19. Malmed
  20. Malphos
  21. Maltox
  22. Maltox MLT
  23. Mercaptosuccinic acid diethyl ester
  24. Mercaptothion
  25. Mercaptotion (Spanish)
  26. Moscarda
  27. NCI - C00215
  28. O,O - Dimethyl S - (1,2 - bis (ethoxycarbonyl) ethyl) dithiophosphate
  29. O,O - Dimethyl S - (1,2 - dicarbethoxyethyl) dithiophosphate
  30. O,O - Dimethyl S - (1,2 - dicarbethoxyethyl) thiothionophosphate
  31. O,O - Dimethyl S - (1,2 - dicarbethoxyethyl) phosphorodithioate
  32. O,O - Dimethyl S - 1,2 - di (ethoxycarbamyl) ethyl phosphorodithioate
  33. O,O - Dimethyl - S - 1,2 - (dicarbaethoxyaethyl) - dithiophosphat (German)
  34. O,O - Dimethyl - S - 1,2 - dikarbetoxylethylditiofosfat (Czech)
  35. O,O - Dimethyldithiophosphate diethylmercaptosuccinate
  36. O,O - Dwumetylo - S - 1,2 - bis (karboetoksyetylo) - dwutiofosforan (Polish)
  37. Oleophosphothion
  38. Ortho malathion
  39. Phosphorodithioic acid, O,O - dimethyl ester, S - ester with diethyl mercaptosuccinate
  40. Phosphothion
  41. Prentox malathion 95% spray
  42. Prioderm
  43. S - (1,2 - Bis (aethoxy - carbonyl) - aethyl) - O,O - dimethyl - dithiophosphat (German)
  44. S - (1,2 - Bis (carbethoxy) ethyl) O,O - dimethyl dithiophosphate
  45. S - (1,2 - Bis (ethoxy - carbonyl) - ethyl) - O,O - dimethyl - dithiofosfaat (Dutch)
  46. S - (1,2 - Bis (ethoxycarbonyl) ethyl) O,O - dimethyl phosphorodithioate
  47. S - (1,2 - Bis (etossi - carbonil) - etil) - O,O - dimetil - ditiofosfato (Italian)
  48. S - (1,2 - Di (ethoxycarbonyl) ethyl) dimethyl phosphorothiolothionate
  49. S - (1,2 - Dicarbethoxyethyl) O,O - dimethyldithiophosphate
  50. S - 1,2 - Bis (ethoxycarbonyl) ethyl - O,O - dimethyl thiophosphate
  51. SF 60
  52. Sadofos
  53. Sadophos


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis intraperitoneal
hamster 		240 mg/kg ARTODN 58,152,1986
cytogenetic analysis hamster lung 76 mg/L GMCRDC 27,95,1981
cytogenetic analysis hamster ovary 303 mg/L EMMUEG 10(Suppl 10),1,1987
cytogenetic analysis human lymphocyte 50 mg/L CYTOAN 54,191,1989
cytogenetic analysis human leukocyte 2 mg/L MUREAV 301,13,1993
cytogenetic analysis mammal (species unspecified) lymphocyte 25 mg/L CUSCAM 57,280,1988
cytogenetic analysis oral
mouse 		14 mg/kg/7 day- continuous FCTOD7 33,309,1995
cytogenetic analysis skin
mouse 		500 mg/kg MUREAV 204,283,1988
cytogenetic analysis oral
mouse 		121 mg/kg/12 week MUREAV 513,1,2002
cytogenetic analysis intraperitoneal
mouse 		5 mg/kg MUREAV 514,223,2002
cytogenetic analysis oral
mouse 		5 mg/kg MUREAV 514,223,2002
cytogenetic analysis oral
mouse 		10 mg/kg/5 day MUREAV 514,223,2002
cytogenetic analysis multiple
other fish 		200 nL/L JFIBA9 26,13,1985
dominant lethal test oral
Drosophila melanogaster 		2,500 ng/L FCTOD7 33,309,1995
DNA damage Escherichia coli 100 mg/L MUREAV 52,161,1978
DNA inhibition human lymphocyte 70 mg/L HUGEDQ 53,375,1980
unscheduled DNA synthesis human lymphocyte 10 mg/L HUGEDQ 56,189,1980
mutation in microorganisms Bacillus subtilis 1 nmol/plate (-enzymatic activation step) MSERDS 5,93,1981
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) CYGEDX 15(3),64,1981
mutation in microorganisms Salmonella typhimurium 10 mg/L (+enzymatic activation step) CYGEDX 15(3),64,1981
micronucleus test human lymphocyte 75 mg/L MUREAV 388,85,1997
other mutation test systems human lymphocyte 10 mg/L HUGEDQ 56,189,1980
other mutation test systems human lymphocyte 70 mg/L ENVRAL 41,372,1986
other mutation test systems human leukocyte 20 µg/L MUREAV 301,13,1993
other mutation test systems mammal (species unspecified) lymphocyte 50 mg/L CUSCAM 57,280,1988
other mutation test systems skin
mouse 		1 gm/kg MUREAV 204,283,1988
sister chromatid exchange hamster ovary 300 µmol/L JTEHD6 8,939,1981
sister chromatid exchange hamster lung 40 mg/L MUREAV 88,307,1981
sister chromatid exchange human lymphocyte 20 mg/L CYTOAN 54,191,1989
sister chromatid exchange human fibroblast 5 mg/L MUREAV 67,167,1979
sister chromatid exchange human leukocyte 20 mg/L MUREAV 301,13,1993
sister chromatid exchange oral
mouse 		121 mg/kg/12 week MUREAV 513,1,2002
sister chromatid exchange intraperitoneal
mouse 		5 mg/kg MUREAV 514,223,2002
sister chromatid exchange oral
mouse 		10 mg/kg/5 day MUREAV 514,223,2002
specific locus test oral
Drosophila melanogaster 		4 µg/L FCTOD7 33,309,1995
sperm morphology intraperitoneal
mouse 		5 mg/kg MUREAV 514,223,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 5,550 mg/kg (91 day prior to copulation/1-20 day pregnant) Reproductive: Specific developmental abnormalities: Body wall JTEHD6 14,267,1984
oral
rat 		lowest published toxic dose: 43,920 mg/kg (multigenerations) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects 		NATUAS 192,464,1961
oral
rat 		lowest published toxic dose: 191 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JFMAAQ 54,452,1967
oral
rat 		lowest published toxic dose: 283 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system JFMAAQ 54,452,1967
oral
rat 		lowest published toxic dose: 20 mg/kg (11-17 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FATOAO 52,87,1989
oral
rat 		lowest published toxic dose: 40 mg/kg (11-17 day pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects FATOAO 52,87,1989
oral
rabbit 		lowest published toxic dose: 540 mg/kg (28-30 day pregnant) Reproductive: Other effects to embryo or fetus MSCREJ 17,743,1989
unreported route
rat 		lowest published toxic dose: 80 mg/kg (2 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		BECTA6 15,458,1976
unreported route
rat 		lowest published toxic dose: 40 mg/kg (11-17 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects 		FATOAO 54,80,1991


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraarterial
cat 		lowest published lethal dose: 1,820 µg/kg N/R 14KTAK -,693,1964
inhalation
cat 		lowest published lethal concentration: 10 mg/m3/4 hour N/R 85GMAT -,56,1982
inhalation
rat 		lethal concentration (50 percent kill): 43,790 µg/m3/4 hour N/R GISAAA 56(2),80,1991
intraperitoneal
dog 		lethal dose (50 percent kill): 1,857 mg/kg N/R TXAPA9 15,244,1969
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 271 mg/kg N/R AEPPAE 236,202,1959
intraperitoneal
hamster 		lethal dose (50 percent kill): 2,400 mg/kg N/R ARTODN 58,152,1986
intraperitoneal
mouse 		lethal dose (50 percent kill): 193 mg/kg N/R PSEBAA 129,699,1968
intraperitoneal
rat 		lethal dose (50 percent kill): 250 mg/kg N/R ARZNAD 22,1926,1972
intravenous
man 		lowest published toxic dose: 14 µL/kg Vascular: Other changes

Skin: After systemic exposure: Dermatitis, other 		JJAMA* 16,367,1992
intravenous
mouse 		lethal dose (50 percent kill): 184 mg/kg N/R BLLIAX 38,151,1958
intravenous
rat 		lethal dose (50 percent kill): 50 mg/kg N/R ARZNAD 5,626,1955
oral
wild bird 		lethal dose (50 percent kill): 400 mg/kg N/R AECTCV 12,355,1983
oral
chicken 		lethal dose (50 percent kill): 600 mg/kg Behavioral: Food intake (animal) IJEBA6 9,455,1971
oral
chicken 		lethal dose (50 percent kill): 1,000 mg/kg N/R HBPTO* 2,957,2001
oral
cattle 		lethal dose (50 percent kill): 53 mg/kg Peripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Rigidity (includes catalepsy) 		IVEJAC 56,650,1979
oral
duck 		lethal dose (50 percent kill): 1,485 µg/kg N/R DOEAAH 35,25,1979
oral
domestic animal 		lethal dose (50 percent kill): 500 mg/kg N/R 85DPAN -,-,1971/1976
oral
guinea pig 		lethal dose (50 percent kill): 570 mg/kg N/R ARZNAD 5,626,1955
oral
man 		lowest published lethal dose: 471 mg/kg Behavioral: Coma

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Dyspnea 		ATXKA8 23,11,1967
oral
mouse 		lethal dose (50 percent kill): 190 mg/kg N/R 85GMAT -,56,1982
oral
rat 		lethal dose (50 percent kill): 290 mg/kg N/R 85GMAT -,56,1982
oral
rat 		lethal dose (50 percent kill): 644 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase FATOAO 53,64,1990
oral
rabbit 		lowest published lethal dose: 1,200 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation AEHA** 99-002-74/1976
oral
woman 		lowest published lethal dose: 8 mL/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes 		FSINDR 95,89,1998
oral
woman 		lowest published toxic dose: 200 µL/kg Behavioral: Coma

Gastrointestinal: Changes in structure or function of exocrine pancreas

Lung, Thorax, or Respiration: Respiratory depression 		IJMDAI 30,855,1994
oral
woman 		lowest published lethal dose: 246 mg/kg Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Skin: After systemic exposure: Dermatitis, other 		AEHLAU 33,240,1978
oral
woman 		lowest published toxic dose: 300 µL/kg Behavioral: Coma

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Cyanosis 		HETOEA 13,271,1994
subcutaneous
guinea pig 		lethal dose (50 percent kill): 450 mg/kg Eye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TPKVAL 7,122,1965
subcutaneous
mouse 		lethal dose (50 percent kill): 221 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase OIZAAV 71,6099,1959
subcutaneous
rat 		lethal dose (50 percent kill): 400 mg/kg Eye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TPKVAL 7,122,1965
subcutaneous
rabbit 		lethal dose (50 percent kill): 280 mg/kg Eye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TPKVAL 7,122,1965
skin
guinea pig 		lethal dose (50 percent kill): 6,700 mg/kg N/R AMCYC* 8/1966
skin
mouse 		lethal dose (50 percent kill): 2,330 mg/kg N/R ABCHA6 27,684,1963
skin
rat 		lethal dose (50 percent kill): >4,444 mg/kg N/R PMJMAQ -,155,1957
skin
rabbit 		lethal dose (50 percent kill): 4,100 mg/kg N/R 28ZEAL 5,142,1976
unreported route
cattle 		lethal dose (50 percent kill): 53 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Change in motor activity (specific assay) 		IJLAA4 49,314,1979
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 500 mg/kg N/R 30ZDA9 -,357,1971
unreported route
mammal (species unspecified) 		lowest published toxic dose: 715 mg/kg Immunological Including Allergic: Decrease in cellular immune response

Blood: Changes in cell count (unspecified) 		HBPTO* 1,773,2001
unreported route
mammal (species unspecified) 		lowest published toxic dose: 0.25 mg/kg Immunological Including Allergic: Decrease in cellular immune response HBPTO* 1,773,2001
unreported route
mouse 		lethal dose (50 percent kill): 375 mg/kg N/R GISAAA 50(3),4,1985
unreported route
rat 		lethal dose (50 percent kill): 124 mg/kg N/R HBPTO* 1,786,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 2,300 µg/m3/4 hour/13 week- intermittent Endocrine: Other changes

Blood: Changes in other cell count (unspecified)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 41(8),93,1976
intraperitoneal
rat 		lowest published toxic dose: 1,050 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Biochemical: Metabolism (intermediary): Lipids including transport 		PHTOEH 61,12,1987
oral
dog 		lowest published toxic dose: 210 mg/kg/12 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase FCTXAV 6,185,1968
oral
dog 		lowest published toxic dose: 175 mg/kg/4 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JPETAB 121,96,1957
oral
domestic animal 		lowest published toxic dose: 150 mg/kg/6 day- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VHTODE 41,287,1999
oral
human 		lowest published toxic dose: 19.04 mg/kg/56 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 1,59,2001
oral
mouse 		lowest published toxic dose: 504 mg/kg/12 week- continuous Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response 		IJEBA6 36,273,1998
oral
mouse 		lowest published toxic dose: 1,500 mg/kg/15 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		BECTA6 63,575,1999
oral
rat 		lowest published toxic dose: 900 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JDGRAX 18,145,1989
oral
rat 		lowest published toxic dose: 462 mg/kg/22 week- continuous Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response 		IJEBA6 36,273,1998
oral
rat 		lowest published toxic dose: 2,250 mg/kg/45 day- intermittent Gastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion) 		BECTA6 33,289,1984
oral
rat 		lowest published toxic dose: 1,050 mg/kg/21 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion) 		AECTCV 14,459,1985
oral
rat 		lowest published toxic dose: 3,358 mg/kg/14 day- continuous Behavioral: Fluid intake

Blood: Change in clotting factors 		JEPOEC 6(1),51,1985
oral
rat 		lowest published toxic dose: 288 mg/kg/90 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HBPTO* 1,59,2001
oral
rat 		lowest published toxic dose: 3,285 mg/kg/730 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 1,59,2001
oral
rat 		lowest published toxic dose: 140 mg/kg/2 week- intermittent Endocrine: Change in gonadotropins

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		BECTA6 18,231,1977
oral
rabbit 		lowest published toxic dose: 368 mg/kg/21 week- intermittent Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response 		IJEBA6 36,273,1998
subcutaneous
guinea pig 		lowest published toxic dose: 18,900 mg/kg/24 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 7,122,1965
subcutaneous
rat 		lowest published toxic dose: 16,800 mg/kg/24 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 7,122,1965
subcutaneous
rabbit 		lowest published toxic dose: 11,760 mg/kg/24 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 7,122,1965
unreported route
rat 		lowest published toxic dose: 5.6 gm/kg/14 day- intermittent Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 2,1035,2001
unreported route
rabbit 		lowest published toxic dose: 1,750 mg/kg/5 week- intermittent Immunological Including Allergic: Decrease in humoral immune response HBPTO* 1,773,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3 (skin) ( intermittent,V) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 30,103,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,103,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
PMDCAY 10,85,1974
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
JTCTDW 38,47,2000
TOXICOLOGY REVIEW
MUREAV 562,77,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,128,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 mg/m3 (skin) DTLVS* 3,148,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3 (skin), total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3 (skin), total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3 (skin), total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 15 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 10 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 10 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 10 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 15 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 15 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 15 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 15 mg/m3, Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MALATHION-air 10 hour time-weighted average 10 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80046;
Number of Industries 13;
Total Number of Facilities 1,609;
Number of Occupations 14;
Total Number of Employees Exposed 17,242
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80046;
Number of Industries 15;
Total Number of Facilities 2,146;
Number of Occupations 18;
Total Number of Employees Exposed 19,170;
Total Number of Female Employees Exposed 1,909


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB2004/100003)
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-human
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
Used as a broad spectrum insecticide and acaricide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
NCI Carcinogenesis Bioassay (feed);no evidence:rat NCITR* NCI-TR-192,1979
OSHA ANALYTICAL METHOD #ID-62


REFERENCES:

CODEN
REFERENCE
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964
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30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
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Used as a broad spectrum insecticide and acaricide

FDA-proprietary drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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