The Registry of Toxic Effects of Chemical Substances

Styrene, p - methyl -

RTECS #: WL5076000

CAS #: 622-97-9

UPDATE: December 2000 MW: 118.19 MF: C9H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1 - Ethenyl - 4 - methylbenzene
  2. Benzene, 1 - ethenyl - 4 - methyl - (9CI)
  3. p - Methylstyrene
  4. 4 - Methylstyrene
  1. 1 - Methyl - 4 - vinylbenzene
  2. 1 - p - Tolylethene
  3. p - Vinyltoluene
  4. 4 - Vinyltoluene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 330 µmol/L CRNGDP 2,237,1981
sister chromatid exchange human lymphocyte 330 µmol/L CRNGDP 2,237,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 581 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		ATDAEI 1,76,1990
intraperitoneal
rat 		lethal dose (50 percent kill): 2,324 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes 		ATDAEI 1,77,1990
intravenous
mouse 		lethal dose (50 percent kill): 280 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes 		ATDAEI 1,76,1990
oral
dog 		lethal dose (50 percent kill): >5 gm/kg Gastrointestinal: Nausea or vomiting

Gastrointestinal: Changes in structure or function of salivary glands

Behavioral: Tremor 		ATDAEI 1,77,1990
oral
mouse 		lethal dose (50 percent kill): 1,072 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		ATDAEI 1,76,1990
oral
rat 		lethal dose (50 percent kill): 2,255 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes 		ATDAEI 1,77,1990
skin
rabbit 		lethal dose (50 percent kill): >5 mL/kg Skin: After systemic exposure: Dermatitis, other ATDAEI 1,77,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,373,1994
International Agency for Research on Cancer (IARC) Cancer Review Animal LACK CARCINOGENICITY IMEMDT 60,373,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 60,373,1994


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (120 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK-2 50 ppm (240 mg/m3), KZG- week 100 ppm (480 mg/m3),JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (491 mg/m3), short term exposure limit 150 ppm, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2573;
Number of Industries 7;
Total Number of Facilities 460;
Number of Occupations 10;
Total Number of Employees Exposed 5,274;
Total Number of Female Employees Exposed 377


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-

RTECS Compound Description:
   Tumorigen
   Mutagen

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