The Registry of Toxic Effects of Chemical Substances
Styrene, alpha - methyl - |
UPDATE: November 2004 | MW: 118.19 | MF: C9H10 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
91 mg
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mild
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AMIHAB 14,387,1956
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skin | rabbit
1,00%
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moderate
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AMIHAB 14,387,1956
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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sister chromatid exchange
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human
lymphocyte
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330 µmol/L
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MUREAV 116,379,1983
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | guinea pig
lowest published lethal concentration: 3,000 ppm
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N/R
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28ZRAQ -,131,1960
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inhalation | human
lowest published toxic concentration: 600 ppm
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Olfaction: Other olfaction effects | Eye: Other eye effects
AMIHAB 14,387,1956
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inhalation | human
lowest published toxic concentration: 600 ppm
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Eye: Conjunctiva irritation | Lung, Thorax, or Respiration: Cough
VCVGH* -,203,1990
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inhalation | rat
lowest published lethal concentration: 3,000 ppm
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N/R
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28ZRAQ -,131,1960
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oral | mouse
lethal dose (50 percent kill): 4,500 mg/kg
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Behavioral: Convulsions or effect on seizure threshold | Lung, Thorax, or Respiration: Cyanosis Nutritional and Gross Metabolic: Body temperature decrease
GISAAA 28(12),14,1963
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oral | mouse
lethal dose (50 percent kill): 50,000 mg/kg
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N/R
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VCVGH* -,203,1990
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oral | rat
lethal dose (50 percent kill): 4,900 mg/kg
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N/R
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AMIHAB 14,387,1956
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skin | rabbit
lowest published lethal dose: 16 mL/kg
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N/R
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UCDS** 5/24/1977
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | guinea pig
lowest published toxic concentration: 3,000 ppm/7 hour/24 week- intermittent
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Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
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VCVGH* -,203,1990
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inhalation | rat
lowest published toxic concentration: 50 mg/m3/6 hour/22 week- intermittent
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Behavioral: Muscle contraction or spasticity | Vascular: BP lowering not characterized in autonomic section Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 28(12),14,1963
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inhalation | rat
lowest published toxic concentration: 5 mg/m3/24 hour/13 week- continuous
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Brain and Coverings: Recordings from specific areas of CNS | Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Other changes
GISAAA 31(2),3,1966
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inhalation | rat
lowest published toxic concentration: 3,000 ppm/7 hour/24 week- intermittent
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Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
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VCVGH* -,203,1990
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oral | mouse
lowest published toxic dose: 15 gm/kg/30 day- intermittent
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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GISAAA 29(4),24,1964
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oral | rat
lowest published toxic dose: 15 gm/kg/30 day- intermittent
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Kidney, Ureter, and Bladder: Proteinuria | Blood: Changes in leukocyte (WBC) count
GTPZAB 23(6),38,1979
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oral | rat
lowest published toxic dose: 1,400 mg/kg/4 week- intermittent
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Kidney, Ureter, and Bladder: Proteinuria | Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGH* -,203,1990
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 50 ppm
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DTLVS* TLV/BEI,2002
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 50 ppm ;short term exposure limit 100 ppm
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DTLVS* TLV/BEI,2003
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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short term exposure limit 100 ppm
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DTLVS* TLV/BEI,2002
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD
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air-ceiling concentration 100 ppm (480 mg/m3)
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DTLVS* 3,170,1971
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
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ceiling concentration 100 ppm (480 mg/m3)
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CFRGBR 29,1910.1000,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
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ceiling concentration 100 ppm (480 mg/m3)
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CFRGBR 29,1926.55,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
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ceiling concentration 100 ppm (480 mg/m3)
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CFRGBR 29,1915.1000,1993
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)
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ceiling concentration 100 ppm (480 mg/m3)
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CFRGBR 41,50-204.50,1994
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Occupational Exposure Limit - AUSTRALIA
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time-weighted average 50 ppm (240 mg/m3), short term exposure limit 100 ppm, JAN1993
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Occupational Exposure Limit - AUSTRIA
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MAK 100 ppm (480 mg/m3), JAN1999
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Occupational Exposure Limit - BELGIUM
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time-weighted average 50 ppm (242 mg/m3), short term exposure limit 100 ppm (484 mg/m3), JAN1993
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Occupational Exposure Limit - DENMARK
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time-weighted average 50 ppm (240 mg/m3), JAN1999
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Occupational Exposure Limit - FINLAND
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time-weighted average 100 ppm (480 mg/m3), short term exposure limit 150 ppm (720 mg/m3), JAN1999
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Occupational Exposure Limit - FRANCE
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VME 50 ppm (240 mg/m3), JAN1999
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Occupational Exposure Limit - GERMANY
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MAK 100 ppm (480 mg/m3), JAN1999
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Occupational Exposure Limit - NORWAY
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time-weighted average 50 ppm (240 mg/m3), JAN1999
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Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 240 mg/m3, 2003
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Occupational Exposure Limit - SWITZERLAND
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MAK- week 50 ppm (240 mg/m3), JAN1999
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Occupational Exposure Limit - THAILAND
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time-weighted average 100 ppm (480 mg/m3), JAN1993
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Occupational Exposure Limit - UNITED KINGDOM
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short term exposure limit 100 ppm (491 mg/m3), SEP2000
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Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | short term exposure limit 100 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
short term exposure limit 100 ppm |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO alpha-METHYLSTYRENE-air
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10 hour time-weighted average 50 ppm; | short term exposure limit 100 ppm
NIOSH* DHHS #92-100,1992
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National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: M1533; | Number of Industries 20; Total Number of Facilities 1,933; Number of Occupations 32; Total Number of Employees Exposed 24,824
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: M1533; |
Number of Industries 3; Total Number of Facilities 354; Number of Occupations 4; Total Number of Employees Exposed 3,214 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used as additive, plasticizer and copolymer
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9275
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501
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NTP Carcinogenesis studies; on test (prechronic studies), October 2000
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REFERENCES:
CODEN
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REFERENCE
28ZRAQ
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"Toxicology and Biochemistry of Aromatic Hydrocarbons," Gerarde, H., New York, Elsevier, 1960
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AMIHAB
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AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher
information, see AEHLAU.
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CFRGBR
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Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402)
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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GISAAA
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Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1936-
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GTPZAB
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Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see
MTPEEI
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MUREAV
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Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NIOSH*
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National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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UCDS**
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Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
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VCVGH*
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"Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances:
Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
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