The Registry of Toxic Effects of Chemical Substances

Styrene, methyl -

RTECS #: WL5075000

CAS #: 25013-15-4

UPDATE: February 2005 MW: 118.19 MF: C9H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 3 - and 4 - Vinyl toluene (mixed isomers)
  2. Ethenylmethylbenzene
  3. Methylstyrene
  4. Methylvinylbenzene
  5. NCI - C56406
  6. Toluene, vinyl - (mixed isomers)
  1. Tolylethylene
  2. Vinyl toluene
  3. Vinyl toluene (ACGIH:OSHA)
  4. Vinyl toluene (mixed isomers)
  5. Vinyltoluene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		90 mg mild AMIHAB 14,387,1956
skin
rabbit 		1,00% moderate AMIHAB 14,387,1956


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
micronucleus test intraperitoneal
mouse 		200 mg/kg TOLED5 8,247,1981
mutation in mammalian somatic cells mouse lymphocyte 60 mg/L EMMUEG 12,85,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 3,750 mg/kg (1-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		SWEHDO 7(Suppl 4),66,1981


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 400 ppm Olfaction: Other olfaction effects

Eye: Other eye effects 		AMIHAB 14,387,1956
inhalation
mouse 		lethal concentration (50 percent kill): 3,020 mg/m3/4 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Other changes

Blood: Hemorrhage 		HYSAAV 34(7-9),334,1969
inhalation
mouse 		lowest published toxic concentration: 2 ppm/6 minute Lung, Thorax, or Respiration: Respiratory depression TOLED5 9,137,1981
inhalation
mouse 		lethal concentration (50 percent kill): 29,500 mg/m3/4 hour N/R VCVGH* -,207,1990
intraperitoneal
rat 		lethal dose (50 percent kill): 2,324 mg/kg Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair 		ATDAEI 1,77,1990
intraperitoneal
rat 		lethal dose (50 percent kill): 1,038 mg/kg N/R VCVGH* -,207,1990
intraperitoneal
rat 		lethal dose (16 percent kill): 747 mg/kg N/R VCVGH* -,207,1990
intraperitoneal
rat 		lethal dose (84 percent kill): 1,761 mg/kg N/R VCVGH* -,207,1990
oral
mouse 		lethal dose (50 percent kill): 3,160 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Other changes

Blood: Hemorrhage 		HYSAAV 34(7-9),334,1969
oral
rat 		lethal dose (50 percent kill): 2,255 mg/kg Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair 		ATDAEI 1,77,1990
skin
mouse 		lowest published lethal dose: 4,500 mg/kg N/R GISAAA 34(9),40,1969
skin
rat 		lowest published lethal dose: 4,500 mg/kg N/R GISAAA 34(9),40,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 29 mg/m3/4 hour/16 week- intermittent Behavioral: Excitement NTIS** OTS0572508
inhalation
mouse 		lowest published toxic concentration: 200 ppm/6 hour/15 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Hepatitis (hepatocellular necrosis), diffuse

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-375,1990
inhalation
mouse 		lowest published toxic concentration: 160 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-375,1990
inhalation
mouse 		lowest published toxic concentration: 618 mg/kg/103 week- intermittent Lung, Thorax, or Respiration: Tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB90-260035
inhalation
mouse 		lowest published toxic concentration: 618 mg/kg/103 week- intermittent Liver: Tumors

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Active as anti-cancer agent 		NTIS** PB90-260035
inhalation
rat 		lowest published toxic concentration: 1,300 ppm/6 hour/15 day- intermittent Eye: Lacrimation

Liver: Other changes

Liver: Changes in liver weight 		NTPTR* NTP-TR-375,1990
inhalation
rat 		lowest published toxic concentration: 332 ppm/6 hour/21 week- intermittent Peripheral Nerve and Sensation: Recording from afferent nerve

Peripheral Nerve and Sensation: Recording from peripheral motor nerve 		TOLED5 30,27,1986
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/6 hour/13 week- intermittent Eye: Lacrimation

Liver: Changes in liver weight 		NTPTR* NTP-TR-375,1990
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour/15 week- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve ATSUDG 5,100,1982
inhalation
rat 		lowest published toxic concentration: 5,000 mg/m3/6 hour/100 day- intermittent Blood: Hemorrhage

Blood: Luekopenia

Blood: Changes in leukocyte (WBC) count 		VCVGH* -,207,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 100 ppm DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,373,1994
International Agency for Research on Cancer (IARC) Cancer Review Animal Lack Carcinogenicity IMEMDT 60,373,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 60,373,1994
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (480 mg/m3) DTLVS* 3,278,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (480 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (480 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (480 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (480 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (240 mg/m3), short term exposure limit 100 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 100 ppm (480 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (242 mg/m3), short term exposure limit 100 ppm (483 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (120 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (240 mg/m3), short term exposure limit 100 ppm (480 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 100 ppm (480 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 50 mg/m3, Skin, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (480 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 50 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 10 ppm (50 mg/m3), KTV 75 ppm (150 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (240 mg/m3) KZG- week 100 ppm (480 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (480 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (491 mg/m3), short term exposure limit 150 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 100 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 100 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL TOLUENE-air 10 hour time-weighted average 100 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 76510;
Number of Industries 61;
Total Number of Facilities 7,016;
Number of Occupations 59;
Total Number of Employees Exposed 73,140
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 76510;
Number of Industries 24;
Total Number of Facilities 2,028;
Number of Occupations 31;
Total Number of Employees Exposed 25,353;
Total Number of Female Employees Exposed 3,889


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in copolymers and as specialty monomer for paint, varnish and polyester preparations
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in copolymers and as specialty monomer for paint, varnish and polyester preparations

NIOSH PROFILE (ARENES), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 1321-45-5
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