The Registry of Toxic Effects of Chemical Substances

Stoddard solvent

RTECS #: WJ8925000

CAS #: 8052-41-3

UPDATE: November 2004 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Naphtha, solvent
  2. Organic solvents, Stoddard solvent
  3. Petroleum distillate fractions
  1. Solvents, naphthas
  2. Stoddard solvent (ACGIH:OSHA)
  3. White spirits


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour moderate ATDAEI 1,32,1990


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 1,700 ppm/7 hour Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		TXAPA9 32,282,1975
inhalation
dog 		lethal concentration : >8 gm/m3/8 hour- continuous Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		TXAPA9 32,282,1975
inhalation
dog 		lowest published lethal concentration: 8,000 mg/m3/3 hour Behavioral: Alteration of classical conditioning VCVPS* -,80,1998
inhalation
rat 		lethal concentration : >5,500 mg/m3/4 hour Behavioral: Somnolence (general depressed activity) ATDAEI 1,32,1990
inhalation
rat 		lowest published lethal concentration: 8,200 mg/m3/8 hour Behavioral: Tremor VCVPS* -,80,1998
oral
rat 		lethal dose : >5 gm/kg Behavioral: Somnolence (general depressed activity) ATDAEI 1,32,1990
skin
rabbit 		lethal dose : >3 gm/kg N/R ATDAEI 1,32,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 330 ppm/65 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Other changes 		TXAPA9 32,282,1975
inhalation
rat 		lowest published toxic concentration: 480 mg/m3/65 day- intermittent Blood: Normocytic anemia VCVPS* -,81,1998
inhalation
rat 		lowest published toxic concentration: 1,100 mg/m3/65 day- intermittent Kidney, Ureter, and Bladder: Renal function tests depressed

Blood: Normocytic anemia 		VCVPS* -,81,1998
skin
rabbit 		lowest published toxic dose: 2 gm/kg/4 week- intermittent Skin: After systemic exposure: Dermatitis, other NTIS** OTS0533989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
TOLED5 128,85,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 500 ppm (2900 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (1150 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (1150 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 500 ppm (2900 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 790 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm (525 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (140 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 200 ppm (1150 mg/m3), JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 575 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 100 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 100 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO STODDARD SOLVENT-air time-weighted average 350 mg/m3;
ceiling concentration 1800 mg/m3/15 minute 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 69855;
Number of Industries 250;
Total Number of Facilities 43,857;
Number of Occupations 135;
Total Number of Employees Exposed 483,167
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 69855;
Number of Industries 404;
Total Number of Facilities 142,653;
Number of Occupations 222;
Total Number of Employees Exposed 1,922,235;
Total Number of Female Employees Exposed 230,356


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264263)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a diluent in paints, coatings and waxes, as dry-cleaning agent, and as a degreaser
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Naphthas, 1550
OSHA ANALYTICAL METHOD #48


REFERENCES:

CODEN
REFERENCE
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

Used as a diluent in paints, coatings and waxes, as dry-cleaning agent, and as a degreaser

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

RTECS Compound Description:
   Primary Irritant

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