The Registry of Toxic Effects of Chemical Substances

2,2' - Stilbenedisulfonic acid, 4,4' - bis ( (4 - anilino - 6 - morpholino - s - triazin - 2 - yl) amino) - , disodium salt

RTECS #: WJ6147000

CAS #: 16090-02-1

UPDATE: October 1997 MW: 925.00 MF: C40H38N12O8S2•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Belotex KD
  2. C.I. Fluorescent Brightener 71
  3. C.I. Fluorescent Brightener 244
  4. C.I. Fluorescent Brightener 250
  5. C.I. Fluorescent Brightener 260
  6. FBA - 260
  7. 4,4' - Bis ( (4 - anilino - 6 - morpholino - 1,3,5 - triazine - 2 - yl) amino) stilbene 2,2 - disulfonate 2Na
  8. Blankophor BBH
  9. Blankophor MBBH
  10. Calcofluor White RC
  11. Disodium 4,4' - bis ( (4 - anilino - 6 - morpholino - 1,3,5 - triazin - 2 - yl) amino) stilbene - 2,2' - disulfonate
  1. Heliofor 3BC
  2. Heliofor BDC
  3. Hiltamine Arctic White DML
  4. Leukopur PAM
  5. MBBH 766
  6. Mikephor TB
  7. Phorwite MBBH 766
  8. Tinopal AMS
  9. Tinopal DMS - X
  10. Tinopal EMS
  11. Stralex MD


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg mild TXAPA9 27,494,1974
eye
rabbit 		100 mg/2S rinse mild TXAPA9 27,494,1974


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
cat 		lowest published lethal dose: >500 mg/kg N/R CCECAU 7,91,1977
oral
guinea pig 		lowest published lethal dose: >1 gm/kg N/R CCECAU 7,91,1977
oral
mouse 		lethal dose (50 percent kill): >20 gm/kg N/R SRTCAC 36(1-4),10,1989
oral
rat 		lethal dose (50 percent kill): >8 gm/kg N/R CCECAU 7,91,1977
oral
rabbit 		lowest published lethal dose: >1 gm/kg N/R CCECAU 7,91,1977
skin
rat 		lethal dose (50 percent kill): >3 gm/kg N/R KHZDAN 29(2),24,1986
skin
rabbit 		lethal dose : >10 gm/kg N/R TXAPA9 27,494,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rat 		lowest published toxic dose: 21 gm/kg/21 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		KHZDAN 29(2),24,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4765;
Number of Industries 2;
Total Number of Facilities 38;
Number of Occupations 3;
Total Number of Employees Exposed 759
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4765;
Number of Industries 1;
Total Number of Facilities 25;
Number of Occupations 1;
Total Number of Employees Exposed 414;
Total Number of Female Employees Exposed 279


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a fluorescent whitening agent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CCECAU Criticial Reviews in Environmental Control. (Chemical Rubber Company, Cleveland, OH) V.1- 1970-
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a fluorescent whitening agent

NIOSH PROFILE (FLUORESCENT WHITENING AGENTS), SRC, 12/79

RTECS Compound Description:
   Mutagen
   Primary Irritant

ALT CAS #: 12646-20-7
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