The Registry of Toxic Effects of Chemical Substances

Stearic acid

RTECS #: WI2800000

CAS #: 57-11-4

UPDATE: August 2004 MW: 284.54 MF: C18H36O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Century 1240
  2. Cetylacetic acid
  3. Dar - chem 14
  4. Emersol 120
  5. Emersol 132
  6. Emersol 150
  7. Formula 300
  8. Hydrofol 1895
  9. Hydrofol acid 1655
  10. Hydrofol acid 1855
  11. HY - Phi 1199
  12. HY - Phi 1205
  13. HY - Phi 1303
  14. HY - Phi 1401
  15. Hystrene 80
  16. Hystrene 4516
  17. Hystrene 5016
  18. Hystrene 7018
  19. Hystrene 9718
  20. Octadecanoic acid
  21. n - Octadecanoic acid
  22. Pearl stearic
  23. Stearex beads
  24. Glycon DP
  25. Glycon S - 70
  26. Glycon S - 80
  1. Glycon S - 90
  2. Glycon TP
  3. Groco 54
  4. Groco 55
  5. Groco 55L
  6. Groco 58
  7. Groco 59
  8. 1 - Heptadecanecarboxylic acid
  9. Industrene 5016
  10. Industrene 8718
  11. Industrene 9018
  12. KAM 1000
  13. KAM 2000
  14. KAM 3000
  15. Neo - fat 18
  16. Neo - fat 18 - S
  17. Neo - fat 18 - 53
  18. Neo - fat 18 - 54
  19. Neo - fat 18 - 55
  20. Neo - fat 18 - 59
  21. Neo - fat 18 - 61
  22. Stearic acid (ACGIH)
  23. Stearophanic acid
  24. Tegostearic 254
  25. Tegostearic 255
  26. Tegostearic 272


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		75 mg/3 day- intermittent mild 85DKA8 -,127,1977
skin
rabbit 		500 mg/24 hour moderate FCTXAV 17,383,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
mouse 		lowest published toxic dose: 400 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		BJCAAI 17,127,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lethal dose (50 percent kill): 23 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		APTOA6 18,141,1961
intravenous
rat 		lethal dose (50 percent kill): 21,500 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		APTOA6 18,141,1961
oral
rat 		lowest published lethal dose: 4,640 mg/kg N/R JACTDZ 6(3),321,1987
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 17,383,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 31,500 mg/kg/30 week- continuous Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		IJOTO* 18,33,1999
oral
rat 		lowest published toxic dose: 313 gm/kg/30 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JACTDZ 14,196,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
AMIHAB 21,100,1960
TOXICOLOGY REVIEW
MUREAV 531,25,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 69740;
Number of Industries 220;
Total Number of Facilities 31,794;
Number of Occupations 159;
Total Number of Employees Exposed 541,742
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7032;
Number of Industries 3;
Total Number of Facilities 136;
Number of Occupations 11;
Total Number of Employees Exposed 9,034;
Total Number of Female Employees Exposed 7,670
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 69740;
Number of Industries 239;
Total Number of Facilities 34,970;
Number of Occupations 165;
Total Number of Employees Exposed 1,123,118;
Total Number of Female Employees Exposed 568,888


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in cosmetics, pharmaceuticals, rubber compounding and in production of stearate salts
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IJOTO* International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V.16- 1997-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

Used in cosmetics, pharmaceuticals, rubber compounding and in production of stearate salts

NIOSH PROFILE (ACIDS, ORGANIC), SRI, 2/77

NIOSH PROFILE (ACIDS, ORGANIC), SRC, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Natural Product
   Primary Irritant

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