The Registry of Toxic Effects of Chemical Substances
Stannane, tricyclohexylhydroxy - RTECS #: WH8750000
CAS #: 13121-70-5
The Registry of Toxic Effects of Chemical Substances
Stannane, tricyclohexylhydroxy - |
| UPDATE: November 2004 | MW: 385.21 | MF: C18H34OSn |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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sister chromatid exchange
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human
lymphocyte
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25 mg/L
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MUREAV 321,219,1994
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | rat
lowest published toxic dose: 108 mg/kg (multigenerations)
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Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
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EQSFAP 4,80,1975
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oral | rabbit
lowest published toxic dose: 23.25 mg/kg (1-31 day pregnant)
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Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
HBPTO* 2,1217,2001
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skin | rabbit
lowest published toxic dose: 3 mg/kg (6-18 day pregnant)
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Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
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HBPTO* 2,1217,2001
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | mouse
lethal concentration (50 percent kill): 290 mg/m3
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N/R
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GTPZAB 28(5),52,1984
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inhalation | rat
lethal concentration (50 percent kill): 244 mg/m3
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N/R
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GISAAA 49(2),74,1984
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intraperitoneal | rat
lethal dose (50 percent kill): 13 mg/kg
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N/R
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DOWCC*
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oral | cat
lethal dose (50 percent kill): >800 mg/kg
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Gastrointestinal: Nausea or vomiting
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EQSFAP 4,80,1975
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oral | chicken
lethal dose (50 percent kill): 654 mg/kg
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N/R
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HBPTO* 2,1216,2001
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oral | dog
lethal dose (50 percent kill): >800 mg/kg
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Gastrointestinal: Nausea or vomiting
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EQSFAP 4,80,1975
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oral | domestic animal
lowest published lethal dose: 150 mg/kg
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Behavioral: Somnolence (general depressed activity) | Behavioral: Food intake (animal) Behavioral: Fluid intake
TXAPA9 31,66,1975
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oral | guinea pig
lethal dose (50 percent kill): 780 mg/kg
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N/R
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HBPTO* 2,1216,2001
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oral | monkey
lethal dose (50 percent kill): >800 mg/kg
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Gastrointestinal: Nausea or vomiting
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EQSFAP 4,80,1975
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oral | mouse
lethal dose (50 percent kill): 275 mg/kg
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Brain and Coverings: Recordings from specific areas of CNS | Peripheral Nerve and Sensation: Recording from peripheral motor nerve
GISAAA 47(7),80,1982
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oral | quail
lethal dose (50 percent kill): 255 mg/kg
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N/R
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EQSFAP 4,80,1975
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oral | rat
lethal dose (50 percent kill): 180 mg/kg
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N/R
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KSKZAN 16(2),59,1978
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oral | rat
lowest published toxic dose: 50 mg/kg
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Behavioral: Food intake (animal) | Gastrointestinal: Hypermotility, diarrhea
HBPTO* 2,1216,2001
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oral | rabbit
lethal dose (50 percent kill): 458 mg/kg
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Brain and Coverings: Recordings from specific areas of CNS | Peripheral Nerve and Sensation: Recording from peripheral motor nerve
GISAAA 47(7),80,1982
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skin | human
lowest published toxic dose: 11 µg/kg/1 day
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Nutritional and Gross Metabolic: Changes in: Other metals
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HBPTO* 2,1218,2001
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skin | rat
lethal dose (50 percent kill): 446 mg/kg
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N/R
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FAATDF 7,299,1986
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skin | rabbit
lethal dose (50 percent kill): 2,422 mg/kg
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Brain and Coverings: Recordings from specific areas of CNS | Peripheral Nerve and Sensation: Recording from peripheral motor nerve
GISAAA 47(7),80,1982
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unreported route | mouse
lethal dose (50 percent kill): 780 mg/kg
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N/R
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TGANAK 16(1),45,1982
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
oral | dog
lowest published toxic dose: 270 mg/kg/90 day- continuous
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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EQSFAP 4,80,1975
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oral | mammal (species unspecified)
lowest published toxic dose: 2,310 mg/kg/44 week- intermittent
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Brain and Coverings: Recordings from specific areas of CNS | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
GISAAA 47(7),80,1982
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oral | mouse
lowest published toxic dose: 1,201 mg/kg/4 day- continuous
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Endocrine: Changes in spleen weight | Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain
PCBPBS 6,270,1976
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oral | mouse
lowest published toxic dose: 8,640 mg/kg/90 day- continuous
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Behavioral: Muscle weakness | Gastrointestinal: Hypermotility, diarrhea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EQSFAP 4,80,1975
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oral | rat
lowest published toxic dose: 180 mg/kg/3 day- intermittent
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Liver: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
GISAAA 49(2),74,1984
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oral | rat
lowest published toxic dose: 2,700 mg/kg/90 day- continuous
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Behavioral: Muscle weakness | Gastrointestinal: Hypermotility, diarrhea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EQSFAP 4,80,1975
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oral | rat
lowest published toxic dose: 2,190 mg/kg/2 year- continuous
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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HBPTO* 2,1217,2001
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oral | rat
lowest published toxic dose: 730 mg/kg/2 year- continuous
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Liver: Other changes
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HBPTO* 2,1217,2001
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oral | rat
lowest published toxic dose: 4,380 mg/kg/2 year- continuous
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Spinal Cord: Other degenerative changes
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HBPTO* 2,1217,2001
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 5 mg/m3
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DTLVS* TLV/BEI,2003
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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Not Classifiable as a Human Carcinogen
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DTLVS* TLV/BEI,2003
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TOXICOLOGY REVIEW
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EQSFAP 4,80,1975
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988
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PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
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FEREAC 54,7740,1989
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Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF
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PESTICIDES: Cancelled
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RBREV* -,106,1998
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
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8 hour time-weighted average 0.1 mg(Sn)/m3
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CFRGBR 29,1910.1000,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
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8 hour time-weighted average 0.1 mg(Sn)/m3
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CFRGBR 29,1926.55,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
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8 hour time-weighted average 0.1 mg(Sn)/m3
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CFRGBR 29,1915.1000,1993
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)
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8 hour time-weighted average 0.1 mg(Sn)/m3
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CFRGBR 41,50-204.50,1994
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Occupational Exposure Limit - AUSTRALIA
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time-weighted average 0.1 mg(Sn)/m3, Skin, JAN1993
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Occupational Exposure Limit - AUSTRIA
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MAK 0.1 mg(Sn)/m3, Skin, JAN1999
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Occupational Exposure Limit - AUSTRALIA
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time-weighted average 5 mg/m3, JAN1993
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Occupational Exposure Limit - BELGIUM
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time-weighted average 5 mg/m3, JAN1993
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Occupational Exposure Limit - DENMARK
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time-weighted average 0.1 mg(Sn)/m3, Skin, JAN1999
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Occupational Exposure Limit - DENMARK
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time-weighted average 5 mg/m3, JAN1999
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Occupational Exposure Limit - FINLAND
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time-weighted average 0.1 mg(Se)/m3, short term exposure limit 0.3 mg(Se)/m3, JAN1999
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Occupational Exposure Limit - FRANCE
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VME 5 mg/m3, JAN1999
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Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 5 mg/m3, 2003
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Occupational Exposure Limit - GERMANY
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MAK 0.1 mg(Sn)/m3, Skin, JAN1999
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Occupational Exposure Limit - HUNGARY
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short term exposure limit 0.1 mg(Sn)/m3, Skin, JAN1993
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Occupational Exposure Limit - NORWAY
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time-weighted average 0.1 mg(Sn)/m3, JAN1999
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Occupational Exposure Limit - THE PHILIPPINES
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time-weighted average 0.1 mg(Sn)/m3, JAN1993
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Occupational Exposure Limit - RUSSIA
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short term exposure limit 0.02 mg/m3, Skin, JAN1993
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Occupational Exposure Limit - SWITZERLAND
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MAK- week 0.1 mg(Sn)/m3, KZG- week 0.2 mg(Sn)/m3, Skin, JAN1999
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Occupational Exposure Limit - THAILAND
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time-weighted average 0.1 mg(Sn)/m3, JAN1993
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Occupational Exposure Limit - UNITED KINGDOM
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time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, SEP2000
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Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
Not Classifiable as a Human Carcinogen | |||||||||||||||||||||
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYHEXATIN-air
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10 hour time-weighted average 5 mg/m3
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NIOSH* DHHS #92-100,1992
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National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ORGANOTIN COMPOUND-air
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10 hour time-weighted average 0.1 mg(Sn)/m3
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NIOSH* DHHS #92-100,1992
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NIOSH Analytical Method, 1994: Organotin compounds as Sn, 5504
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REFERENCES:
CODEN
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REFERENCE
CFRGBR
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Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402)
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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EQSFAP
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Environmental Quality and Safety. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1972-76. Discontinued.
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FAATDF
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Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1-40, 1981-97. For publisher information, see TOSCF2
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FEREAC
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Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
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GISAAA
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Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1936-
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GTPZAB
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Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see
MTPEEI
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HBPTO*
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Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
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KSKZAN
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Khimiya v Sel'skom Khozyaistve. Chemistry in Agriculture. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) No.1- 1963-
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MUREAV
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Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NIOSH*
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National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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PCBPBS
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Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802) V.1- 1971-
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RBREV*
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Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report),
Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental
Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
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TGANAK
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Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
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TXAPA9
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Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959-
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