The Registry of Toxic Effects of Chemical Substances

Stannane, dibutyloxo -

RTECS #: WH7175000

CAS #: 818-08-6

UPDATE: May 2004 MW: 248.95 MF: C8H18OSn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. DBOT
  2. Dibutyltin oxide
  3. Di - n - butyltin oxide
  4. Di - n - butyl - zinn - oxyd (German)
  5. Dibutyloxide of tin
  6. Dibutyloxostannane
  1. Dibutyloxotin
  2. Dibutylstannane oxide
  3. Dibutylstannium oxide
  4. Kyslicnik di - n - butylcinicity (Czech)
  5. Tin, dibutyl - , oxide
  6. Tin, dibutyloxo -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe NTIS** OTS0555391
skin
rabbit 		500 mg/24 hour mild 85JCAE -,1248,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 19,916 µg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TXCYAC 85,149,1993


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 40 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity) 		FCTXAV 7,47,1969
oral
rat 		lethal dose (50 percent kill): 44,900 µg/kg N/R 85JCAE -,1248,1986
oral
rabbit 		lowest published lethal dose: 1,500 mg/kg N/R SAIGBL 15,3,1973
skin
rabbit 		lethal dose : >2 gm/kg Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes

Skin: After systemic exposure: Dermatitis, other 		NTIS** OTS0570737


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 31,200 µg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count 		GISAAA 42(4),14,1977


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg(Sn)/m3;short term exposure limit 0.2 mg/m3 (skin) DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,1999
TOXICOLOGY REVIEW
EVHPAZ 4,61,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg(Sn)/m3 DTLVS* 3,258,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Sn)/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 mg(Sn)/m3, Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(Sn)/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg(Sn)/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Se)/m3, short term exposure limit 0.3 mg(Se)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg(Sn)/m3, 0.2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 mg(Sn)/m3, Skin, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 0.1 mg(Sn)/m3, Skin, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Sn)/m3, KZG- week 0.2 mg(Sn)/m3, Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as a human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as a human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ORGANOTIN COMPOUND-air 10 hour time-weighted average 0.1 mg(Sn)/m3 NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0245;
Number of Industries 8;
Total Number of Facilities 503;
Number of Occupations 9;
Total Number of Employees Exposed 4,009;
Total Number of Female Employees Exposed 691


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Organometallic
   Reproductive Effector
   Primary Irritant

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