The Registry of Toxic Effects of Chemical Substances

Stannane, dibutylbis (lauroyloxy) -

RTECS #: WH7000000

CAS #: 77-58-7

UPDATE: May 2004 MW: 631.65 MF: C32H64O4Sn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Davainex
  2. DBTL
  3. Dibutyltin dilaurate
  4. Dibutyltin n - dodecanoate
  5. Dibutyltin laurate
  6. Dibutyl - zinn - dilaurat (German)
  7. Dibutylbis (laurato) tin
  8. Dibutylbis (lauroyloxy) tin
  9. Dibutylstannium dilaurate
  10. DXR 81
  11. Fomrez sul - 4
  12. Mark 1038
  13. Mark BT 11
  14. Mark BT 18
  15. Ongrostab BLTM
  16. Bis (lauroyloxy) di (n - butyl) stannane
  17. Butynorate
  18. Cata - Chek 820
  19. Kosmos 19
  20. KS 20
  21. Lankromark LT 173
  22. Laudran di - n - butylcinicity (Czech)
  1. Lauric acid, dibutylstannylene salt
  2. Lauric acid, dibutyltin deriv.
  3. Laustan - B
  4. Neostann U 100
  5. SM 2014C
  6. Stabilizer D - 22
  7. Stanclere DBTL
  8. Stannane, bis (dodecanoyloxy) di - n - butyl -
  9. Stannane, bis (lauroyloxy) dibutyl -
  10. Stannane, dibutylbis ( (1 - oxododecyl) oxy) -
  11. Stavincor 1200 SN
  12. Therm chek 820
  13. Thermolite T 12
  14. Tin, dibutylbis (lauroyloxy) -
  15. Tin, di - n - butyl - , di (dodecanoate)
  16. Tin dibutyl dilaurate
  17. Tinostat
  18. TN 12
  19. TN 12 (catalyst)
  20. TVS Tin Lau
  21. TVS - TL 700


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/24 hour moderate 28ZPAK -,230,1972
skin
rabbit 		500 mg severe NTIS** OTS0555424


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 50,532 µg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TXCYAC 85,149,1993


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 2,400 mg/m3 N/R MTPEEI (4),36,1995
inhalation
mouse 		lethal concentration (50 percent kill): 150 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in bone marrow not included in above 		STGNBT -,66,1999
intraperitoneal
mouse 		lethal dose (50 percent kill): 180 mg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands 		MTPEEI (4),36,1995
intraperitoneal
rat 		lowest published lethal dose: 85 mg/kg N/R BJPCAL 10,16,1955
intravenous
rat 		lethal dose (50 percent kill): 33 mg/kg Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in bone marrow not included in above 		STGNBT -,66,1999
oral
mouse 		lethal dose (50 percent kill): 210 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands 		MTPEEI (4),36,1995
oral
rat 		lethal dose (50 percent kill): 175 mg/kg N/R ARZNAD 10,44,1960
oral
rabbit 		lethal dose (50 percent kill): 100 mg/kg Behavioral: Somnolence (general depressed activity)

Liver: Fatty liver degeneration

Blood: Pigmented or nucleated red blood cells 		STGNBT -,66,1999
skin
rabbit 		lethal dose : >2 gm/kg Gastrointestinal: Hypermotility, diarrhea

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555424


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 120 mg/kg/3 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Biochemical: Metabolism (intermediary): Lipids including transport 		TOLED5 57,245,1991
oral
rat 		lowest published toxic dose: 262 mg/kg/15 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		DCTODJ 4,75,1981
oral
rat 		lowest published toxic dose: 20 mg/kg/2 week- intermittent Endocrine: Changes in thymus weight IITOEF 16,645,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg(Sn)/m3;short term exposure limit 0.2 mg/m3 (skin) DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,1999
TOXICOLOGY REVIEW
EVHPAZ 4,61,1973
TOXICOLOGY REVIEW
EQSFAP 4,80,1975


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg(Sn)/m3 DTLVS* 3,258,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg(Sn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Sn)/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 mg(Sn)/m3, Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(Sn)/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg(Sn)/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Se)/m3, short term exposure limit 0.3 mg(Se)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg(Sn)/m3, VLE 0.2 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 mg(Sn)/m3, Skin, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 0.1 mg(Sn)/m3, Skin, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg(Sn)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Sn)/m3, KZG- week 0.2 mg(Sn)/m3, Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg(Sn)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(Sn)/m3, short term exposure limit 0.2 mg(Sn)/m3, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as a human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as a human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ORGANOTIN COMPOUND-air 10 hour time-weighted average 0.1 mg(Sn)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83554;
Number of Industries 19;
Total Number of Facilities 413;
Number of Occupations 30;
Total Number of Employees Exposed 7,628
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83554;
Number of Industries 93;
Total Number of Facilities 8,868;
Number of Occupations 64;
Total Number of Employees Exposed 118,739;
Total Number of Female Employees Exposed 24,525


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as PVC heat stabilizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSFAP Environmental Quality and Safety. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1972-76. Discontinued.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
IITOEF Immunopharmacology and Immunotoxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.9- 1987-
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow, Russia) No.1- 1993-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as PVC heat stabilizer

RTECS Compound Description:
   Organometallic
   Reproductive Effector
   Primary Irritant

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