The Registry of Toxic Effects of Chemical Substances

Spinosad

[Isolated from Saccharopolyspora spinosa (Actinomycetes) (HBPTO* 1,140,2001)]

RTECS #: WG9110000

CAS #: 168316-95-8

UPDATE: November 2004 MW: 1,477.96 MF: C41H65NO10•C42H67NO10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. REFERENCES:

SYNONYMS:

  1. Spinosad technical


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 2,025 mg/kg (90 day male/90 day prior to copulation) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina 		FEREAC 67,60923,2002
unreported route
mammal (species unspecified) 		lowest published toxic dose: 2.68 mg/kg (multigenerations) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		FEREAC 66,1594,2001
unreported route
mammal (species unspecified) 		lowest published toxic dose: 100 mg/kg (multigenerations) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		FEREAC 64,28364,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >5.18 mg/m3 N/R HBPTO* 1,140,2001
oral
duck 		lethal dose (50 percent kill): >2,000 mg/kg N/R HBPTO* 1,140,2001
oral
duck 		lethal dose (50 percent kill): 5,000 ppm N/R HBPTO* 1,140,2001
oral
mouse 		lethal dose (50 percent kill): 5,000 mg/kg N/R FEREAC 64,28364,1999
oral
quail 		lethal dose (50 percent kill): >2,000 mg/kg N/R HBPTO* 1,140,2001
oral
quail 		lethal concentration (50 percent kill): 5,000 ppm N/R HBPTO* 1,140,2001
oral
rat 		lethal dose (50 percent kill): 3,738 mg/kg N/R FEREAC 64,28364,1999
skin
rat 		lethal dose (50 percent kill): 2,800 mg/kg N/R FEREAC 64,51453,1999
skin
rabbit 		lethal dose (50 percent kill): 5,000 mg/kg N/R FEREAC 64,28364,1999


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 875.7 mg/kg/90 day- intermittent Liver: Other changes

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 67,60923,2002
oral
mouse 		lowest published toxic dose: 1,876.9 mg/kg/13 week- intermittent Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TOSCF2 65,276,2002
oral
mouse 		lowest published toxic dose: 7,260 mg/kg/44 day- intermittent Liver: Multiple effects

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOSCF2 65,276,2002
oral
mouse 		lowest published toxic dose: 2,025 mg/kg/90 day- intermittent Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		FEREAC 67,60923,2002
oral
rat 		lowest published toxic dose: 3,084.9 mg/kg/13 week- intermittent Liver: Other changes

Gastrointestinal: Changes in structure or function of exocrine pancreas

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		TOSCF2 65,288,2002
oral
rat 		lowest published toxic dose: 9,492 mg/kg/5 week- intermittent Liver: Multiple effects

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOSCF2 65,288,2002
oral
rat 		lowest published toxic dose: 6,165 mg/kg/90 day- intermittent Endocrine: Adrenal cortex hypoplasia FEREAC 67,60923,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,393,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-

RTECS Compound Description:
   Agricultural Chemical
   Natural Product

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