The Registry of Toxic Effects of Chemical Substances

Sorbic acid

RTECS #: WG2100000

CAS #: 110-44-1

UPDATE: October 1998 MW: 112.14 MF: C6H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Panosorb
  2. 1,3 - Pentadiene - 1 - carboxylic acid
  3. 2 - Propenylacrylic acid
  4. trans - trans - 2,4 - Hexadienoic acid
  5. 2E,4E - Hexadienoic acid
  6. Kyselina 1,3 - pentadien - 1 - karboxylova (Czech)
  7. Kyselina sorbova (Czech)
  8. trans,trans - Sorbic acid
  1. Sorbistat
  2. Acetic acid, (2 - butenylidene) -
  3. Acetic acid, crotylidene -
  4. Hexadienic acid
  5. Hexadienoic acid
  6. (E,E) - 2,4 - Hexadienoic acid
  7. 2,4 - Hexadienoic acid, (E,E) - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
man 		150 mg/1 hour severe JPPMAB 10,719,1958
skin
rabbit 		1 mg severe UCDS** 7/14/1965


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 1,050 mg/L FCTOD7 22,501,1984
sister chromatid exchange hamster lung 1,050 mg/L FCTOD7 22,501,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 1,040 mg/kg/65 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		BJCAAI 20,134,1966


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 2,820 mg/kg N/R JPPMAB 21,85,1969
intraperitoneal
rat 		lethal dose (50 percent kill): 800 mg/kg N/R 38MKAJ 2C,4953,1982
oral
mouse 		lethal dose (50 percent kill): 3,200 mg/kg N/R 38MKAJ 2C,4953,1982
oral
rat 		lethal dose (50 percent kill): 7,360 mg/kg N/R JIHTAB 30,63,1948
subcutaneous
mouse 		lethal dose (50 percent kill): 2,820 mg/kg N/R JPPMAB 21,85,1969
skin
rabbit 		lethal dose : >1 gm/kg N/R UCDS** 7/14/1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81510;
Number of Industries 6;
Total Number of Facilities 583;
Number of Occupations 11;
Total Number of Employees Exposed 4,662
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81510;
Number of Industries 45;
Total Number of Facilities 4,412;
Number of Occupations 59;
Total Number of Employees Exposed 69,243;
Total Number of Female Employees Exposed 21,637


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as a food preservative against fungi, yeast and bacteria

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Primary Irritant

ALT CAS #: 91751-55-2
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