The Registry of Toxic Effects of Chemical Substances

Sodium sulfite (2:1)

RTECS #: WE2150000

CAS #: 7757-83-7

UPDATE: August 2003 MW: 126.04 MF: O3S•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Anhydrous sodium sulfite
  2. Disodium sulfite
  3. Exsiccated sodium sulfite
  4. Sodium sulfite
  5. Natriumsulfit (German)
  6. Sodium sulfite anhydrous
  1. Sodium sulphite
  2. Sulftech
  3. Sulfurous acid, disodium salt
  4. Sulfurous acid, sodium salt (1:2)
  5. S - WAT


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis cattle other cell types 250 mg/L ENVRAL 9,84,1975
cytogenetic analysis domestic animal other cell types 250 mg/L ENVRAL 9,84,1975
cytogenetic analysis mouse other cell types 25 mg/L ENVRAL 9,84,1975
mutation in microorganisms other microorganisms 600 ppm (-enzymatic activation step) POASAD 34,114,1953
other mutation test systems human lymphocyte 100 µmol/L CHRTBC 4,211,1973
sperm morphology cattle other cell types 250 mg/L ENVRAL 9,84,1975
sperm morphology domestic animal other cell types 250 mg/L ENVRAL 9,84,1975
sperm morphology mouse other cell types 25 mg/L ENVRAL 9,84,1975


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 950 mg/kg N/R ARZNAD 31,1713,1981
intravenous
cat 		lowest published lethal dose: 400 mg/kg N/R AHYGAJ 57,87,1906
intravenous
guinea pig 		lowest published lethal dose: 200 mg/kg N/R HBAMAK 4,1289,1935
intravenous
mouse 		lethal dose (50 percent kill): 175 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		JPETAB 101,101,1951
oral
mouse 		lethal dose (50 percent kill): 820 mg/kg N/R TRENAF 27,159,1976
oral
rat 		lethal dose (50 percent kill): 3,560 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Skin and Appendages: Other: Hair 		IJTOFN 19,349,2000
oral
rabbit 		lowest published lethal dose: 2,825 mg/kg N/R AHYGAJ 57,87,1906
subcutaneous
cat 		lowest published lethal dose: 1,300 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
dog 		lowest published lethal dose: 1,300 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
guinea pig 		lowest published lethal dose: 600 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
rabbit 		lowest published lethal dose: 600 mg/kg N/R AHYGAJ 57,87,1906


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 54,131,1992
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 54,131,1992
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 54,131,1992


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,321,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5886;
Number of Industries 177;
Total Number of Facilities 31,580;
Number of Occupations 116;
Total Number of Employees Exposed 309,663;
Total Number of Female Employees Exposed 122,038


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as reducing agent, in boiler water treatment, food applications
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AHYGAJ Archiv fuer Hygiene. (Munich, Fed. Rep. Ger.) V.1-100, 1883-1928. For publisher information, see ZHPMAT.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CHRTBC Chromosomes Today. (George Allen & Unwin Ltd., 40 Museum St., London WC1A 1LU, UK) V.1- 1966-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
POASAD Proceedings of the Oklahoma Academy of Science. (Oklahoma Academy of Science, c/o Executive Secretary-Treasurer, Southwestern Oklahoma State Univ., Weatherford, OK 73096) V.1- 1910/1920-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50-

Used as reducing agent, in boiler water treatment, food applications

RTECS Compound Description:
   Tumorigen
   Mutagen

ALT CAS #: 10579-83-6
ALT CAS #: 68135-69-3
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