The Registry of Toxic Effects of Chemical Substances

Sodium bicarbonate (1:1)

RTECS #: VZ0950000

CAS #: 144-55-8

UPDATE: October 1997 MW: 84.01 MF: CHO3•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Baking soda
  2. Bicarbonate of soda
  3. Col - evac
  4. Monosodium carbonate
  5. Carbonic acid monosodium salt
  1. Jusonin
  2. NEUT
  3. Sodium acid carbonate
  4. Soda mint
  5. Sodium hydrogen carbonate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/30S mild TXCYAC 23,281,1982
skin
human 		30 mg/3 day- intermittent mild 85DKA8 -,127,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis oral
rat 		50,400 mg/kg/4 week- continuous CRNGDP 9,1203,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 40 mg/kg (7 day pregnant) Reproductive: Other developmental abnormalities POASAD 56,10,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >900 mg/m3 N/R GTPZAB 33(5),30,1989
oral
infant 		lowest published toxic dose: 1,260 mg/kg Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Urine volume increased

Nutritional and Gross Metabolic: Changes in: Na 		AJDCAI 135,965,1981
oral
man 		lowest published toxic dose: 20 mg/kg/5 day- intermittent Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Changes in: K

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis 		AJEMEN 12,57,1994
oral
mouse 		lethal dose (50 percent kill): 3,360 mg/kg N/R GTPZAB 33(5),30,1989
oral
rat 		lethal dose (50 percent kill): 4,220 mg/kg N/R TXAPA9 6,726,1964


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 77,200 µg/kg/17 week Cardiac: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Na 		GTPZAB 33(5),30,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
JRPMAP 12,27,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80069;
Number of Industries 158;
Total Number of Facilities 27,050;
Number of Occupations 111;
Total Number of Employees Exposed 236,575
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9090;
Number of Industries 1;
Total Number of Facilities 38;
Number of Occupations 4;
Total Number of Employees Exposed 1,325;
Total Number of Female Employees Exposed 1,035
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80069;
Number of Industries 206;
Total Number of Facilities 30,686;
Number of Occupations 169;
Total Number of Employees Exposed 881,879;
Total Number of Female Employees Exposed 416,265


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969-
POASAD Proceedings of the Oklahoma Academy of Science. (Oklahoma Academy of Science, c/o Executive Secretary-Treasurer, Southwestern Oklahoma State Univ., Weatherford, OK 73096) V.1- 1910/1920-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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