The Registry of Toxic Effects of Chemical Substances

Sodium bisulfite (1:1)

RTECS #: VZ2000000

CAS #: 7631-90-5

UPDATE: November 2004 MW: 104.06 MF: HO3S•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Bisulfite de sodium (French)
  2. Hydrogen sulfite sodium
  3. Monosodium sulfite
  4. Sodium acid sulfite
  5. Sodium bisulfite
  1. Sodium bisulfite (ACGIH)
  2. Sodium bisulphite
  3. Sodium hydrogen sulfite
  4. Sodium sulhydrate
  5. Sulfurous acid, monosodium salt


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster embryo 40 mmol/L CNREA8 48,7246,1988
cytogenetic analysis human lymphocyte 375 µmol/L TECSDY 8,39,1984
DNA damage other microorganisms 3 mole/L BBRCA9 39,156,1970
DNA damage other microorganisms 3 mole/L/96 hour- continuous NARHAD 8,4777,1980
DNA damage Saccharomyes cerevisiae 3,200 mmol/L JBCHA3 252,2566,1977
mutation in microorganisms Escherichia coli 1 mole/L (-enzymatic activation step) BBRCA9 39,983,1970
mutation in microorganisms Haemophilus influenzae 200 mmol/L (-enzymatic activation step) ABMPAC 17,115,1980
mutation in microorganisms other microorganisms 3 mole/L (-enzymatic activation step) BBRCA9 39,156,1970
mutation in microorganisms other microorganisms 180 mmol/L (-enzymatic activation step) GENTAE 68,603,1971
mutation in microorganisms Salmonella typhimurium 100 mmol/L (+enzymatic activation step) TCMUD8 5,195,1985
micronucleus test human lymphocyte 100 µmol/L MUREAV 298,63,1992
morphological transform hamster embryo 5 mmol/L CRNGDP 11,1869,1990
other mutation test systems human lymphocyte 50 µmol/L MUREAV 298,63,1992
sister chromatid exchange hamster embryo 500 µmol/L CRNGDP 11,1869,1990
sister chromatid exchange human lymphocyte 50 µmol/L MUREAV 298,63,1992
specific locus test non-mammalian species other cell types 4 mole/L PNASA6 79,1388,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
dog 		lethal dose (50 percent kill): 244 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory depression 		CLPTAT 9,328,1968
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 779 mg/kg N/R TXAPA9 44,251,1978
intraperitoneal
hamster 		lethal dose (50 percent kill): 487 mg/kg N/R CEHYAN 22,64,1977
intraperitoneal
mouse 		lethal dose (50 percent kill): 675 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory depression 		CLPTAT 9,328,1968
intraperitoneal
rat 		lethal dose (50 percent kill): 475 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold 		PNASA6 70,3655,1973
intraperitoneal
rabbit 		lethal dose (50 percent kill): 300 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory depression 		CLPTAT 9,328,1968
intravenous
hamster 		lethal dose (50 percent kill): 95 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		JPETAB 101,101,1951
intravenous
mouse 		lethal dose (50 percent kill): 130 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		JPETAB 101,101,1951
intravenous
rat 		lethal dose (50 percent kill): 115 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		JPETAB 101,101,1951
intravenous
rabbit 		lethal dose (50 percent kill): 65 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		JPETAB 101,101,1951
oral
rat 		lethal dose (50 percent kill): 2 gm/kg N/R 85INA8 6,1408,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 4,381 mg/kg/21 day- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		GISAAA 44(10),62,1979
intravenous
rabbit 		lowest published toxic dose: 450 mg/kg/3 week- intermittent Vascular: Thromobosis distant from injection site

Skin: After systemic exposure: Dermatitis, other 		JPETAB 101,101,1951


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 54,131,1992
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 54,131,1992
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 54,131,1992


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,320,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SODIUM BISULFITE-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1055;
Number of Industries 147;
Total Number of Facilities 23,628;
Number of Occupations 92;
Total Number of Employees Exposed 133,191
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1055;
Number of Industries 144;
Total Number of Facilities 22,338;
Number of Occupations 110;
Total Number of Employees Exposed 296,327;
Total Number of Female Employees Exposed 119,535


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Rodent heritable translocation
EPA GENETOX PROGRAM 1988, Negative: Mouse specific locus; TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as disinfectant, bleach, antioxidant and as inhibitor of yeast and bateria in winemaking
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
ABMPAC Advances in Biological and Medical Physics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-17, 1948-80.
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
CEHYAN Ceskoslovenska Hygiena. Czechoslovak Hygiene. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1956-
CLPTAT Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264) V.1- 1916-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore, MD 21202) V.1- 1905-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NARHAD Nucleic Acids Research. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1974-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as disinfectant, bleach, antioxidant and as inhibitor of yeast and bateria in winemaking

NIOSH PROFILE (PHOTOGRAPHIC PROCESSING), FIRL, 4/78

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

ALT CAS #: 57414-01-4
ALT CAS #: 69098-86-8
ALT CAS #: 89830-27-3
ALT CAS #: 91829-63-9
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