The Registry of Toxic Effects of Chemical Substances

Silver (I) nitrate (1:1)

RTECS #: VW4725000

CAS #: 7761-88-8

UPDATE: August 2004 MW: 169.88 MF: NO3•Ag


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Lunar caustic
  2. Nitrate d'argent (French)
  3. Nitric acid, silver (1+) salt
  1. Silbernitrat
  2. Silver nitrate
  3. Silver (1+) nitrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		1 mg severe AROPAW 25,839,1941
eye
rabbit 		10 mg moderate TXAPA9 55,501,1980


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition human lymphocyte 76 µmol/L IAAAAM 79,83,1986
DNA inhibition intraperitoneal
mouse 		20 gm/kg ARGEAR 51,605,1981
morphological transform hamster embryo 60 µmol/L CNREA8 39,193,1979
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 140 ppb ANYAA9 407,186,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratesticular
dog 		lowest published toxic dose: 20 mg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct AEFTAA 6,349,1975
intratesticular
rat 		lowest published toxic dose: 3,398 µg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JRPFA4 7,21,1964
intratesticular
rat 		lowest published toxic dose: 400 mg/kg (1 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) FESTAS 24,884,1973
oral
rat 		lowest published toxic dose: 28,560 mg/kg (17 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) GTPZAB 27(12),33,1983
subcutaneous
dog 		lowest published toxic dose: 50 mg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct FESTAS 24,884,1973
subcutaneous
mouse 		lowest published toxic dose: 13,590 µg/kg (30 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JRPFA4 7,21,1964
subcutaneous
rat 		lowest published toxic dose: 13,590 µg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 15 gm/kg/19 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		NCIMAV 10,489,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
guinea pig 		lowest published lethal dose: 216 mg/kg N/R AEHLAU 11,201,1965
intraperitoneal
mouse 		lethal dose (50 percent kill): 17 mg/kg N/R GTPZAB 27(12),33,1983
intraperitoneal
rat 		lethal dose (50 percent kill): 83 mg/kg N/R GTPZAB 27(12),33,1983
intravenous
rabbit 		lowest published lethal dose: 8,800 µg/kg N/R EQSSDX 1,1,1975
oral
dog 		lowest published lethal dose: 20 mg/kg N/R HBAMAK 4,1289,1935
oral
guinea pig 		lethal dose (50 percent kill): 473 mg/kg Behavioral: Tetany

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Hypermotility, diarrhea 		GTPZAB 27(12),33,1983
oral
mouse 		lethal dose (50 percent kill): 50 mg/kg N/R JPPMAB 2,20,1950
oral
rat 		lethal dose (50 percent kill): 1,173 mg/kg Behavioral: Tetany

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Hypermotility, diarrhea 		GTPZAB 27(12),33,1983
oral
rabbit 		lowest published lethal dose: 800 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
guinea pig 		lowest published lethal dose: 62 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea 		BMJOAE 2,217,1913
unreported route
human 		lowest published lethal dose: 140 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		VCVN1* -,83,1998
unreported route
man 		lowest published lethal dose: 29 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 12 mg/m3/17 week- intermittent Cardiac: Pulse rate increased without fall in BP

Kidney, Ureter, and Bladder: Urine volume increased

Blood: Changes in erythrocyte (RBC) count 		GTPZAB 27(12),33,1983
oral
mouse 		lowest published toxic dose: 2,250 mg/kg/18 week- continuous Behavioral: Somnolence (general depressed activity) APTOA6 55,398,1984
oral
mouse 		lowest published toxic dose: 0.42 mg/kg/1 week- intermittent Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Urine volume increased 		TXCYAC 186,151,2003
oral
rat 		lowest published toxic dose: 28,560 mg/kg/17 week- intermittent Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		GTPZAB 27(12),33,1983
oral
rat 		lowest published toxic dose: 14 gm/kg/13 week- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NETOD7 1,275,1979
oral
rat 		lowest published toxic dose: 0.7 mg/kg/14 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Interstitial nephritis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVN1* -,84,1988
oral
rat 		lowest published toxic dose: 652 mg/kg/4 day- intermittent Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation TOXID9 72,246,2003
oral
turkey 		lowest published toxic dose: 113,400 mg/kg/18 week- continuous Cardiac: Cardiomegaly

Cardiac: Changes in heart weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVN1* -,84,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg(Ag)/m3 DTLVS* TLV/BEI,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,335,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.01 mg(Ag)/m3 DTLVS* 3,231,1971
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.01 mg(Ag)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.01 mg(Ag)/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.01 mg(Ag)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.01 mg(Ag)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.01 mg(Ag)/m3, short term exposure limit 0.03 mg(Ag)/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.01 mg(Ag)/m3, JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.01 mg(Ag)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg(Ag)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.01 mg(Ag)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.01 mg(Ag)/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.01 mg(Ag)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND time-weighted average 0.01 mg(Ag)/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.01 mg(Ag)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.01 mg(Ag)/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.01 mg(Ag)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80142;
Number of Industries 76;
Total Number of Facilities 3,772;
Number of Occupations 40;
Total Number of Employees Exposed 27,982
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80142;
Number of Industries 95;
Total Number of Facilities 7,884;
Number of Occupations 69;
Total Number of Employees Exposed 176,015;
Total Number of Female Employees Exposed 99,042


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AEFTAA Acta Europaea Fertilitatis. (COFESE Eds., Piazzale Ungheria 73, 90141 Palermo, Italy) V.1- 1969-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
IAAAAM International Archives of Allergy and Applied Immunology. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1950-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1959-
NETOD7 Neurobehavioral Toxicology. (Fayetteville, NY) V.1-2, 1979-80. For publisher information, see NTOTDY.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used as starting material in production of other silver compounds

NIOSH PROFILE (PHOTOGRAPHIC PROCESSING), FIRL, 4/78

NIOSH PROFILE (SILVER AND ITS COMPOUNDS), SRC, 4/78

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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