The Registry of Toxic Effects of Chemical Substances

Silicic acid, tetramethyl ester

RTECS #: VV9800000

CAS #: 681-84-5

UPDATE: November 2004 MW: 152.25 MF: C4H12O4Si


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Methyl silicate
  2. Methyl silicate (ACGIH)
  3. Silicic acid, methyl ester of ortho -
  4. TL 190
  1. Tetramethoxysilane
  2. Tetramethyl silicate
  3. Tetramethylsilikat (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 1 gm/m3/10 minute Eye: Other eye effects

Musculoskeletal: Other changes 		NDRC** NDCrc-132,MAY1942
inhalation
rat 		lowest published lethal concentration: 250 ppm/4 hour N/R AMIHBC 4,119,1951
intraperitoneal
mouse 		lethal dose (50 percent kill): 250 mg/kg N/R CBCCT* 2,56,1950
intraperitoneal
rat 		lethal dose (50 percent kill): 100 mg/kg N/R 85JCAE -,1222,1986
intravenous
rabbit 		lowest published lethal dose: 100 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		30ZNA5 3,935,1968
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 1 gm/kg N/R GISAAA 39(4),86,1974
oral
rat 		lowest published lethal dose: 700 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 30ZNA5 3,935,1968
skin
rabbit 		lethal dose (50 percent kill): 17 mL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 30 ppm/6 hour/28 day- intermittent Behavioral: Food intake (animal)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		NTIS** OTS0523612
inhalation
rat 		lowest published toxic concentration: 20 ppm/6 hour/5 day- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage 		NTIS** OTS0523612


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 5 ppm (30 mg/m3) DTLVS* 3,169,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (30 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (30 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (6 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (30 mg/m3), short term exposure limit 10 ppm (60 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (6 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 1 ppm (6 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (6 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 6 mg/m3, 2003
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 ppm (6.3 mg/m3), short term exposure limit 5 ppm (32 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL SILICATE-air 10 hour time-weighted average 1 ppm NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZNA5 "Dangerous Properties of Industrial Materials," Sax, N.I., New York, Van Nostrand Reinhold, 1980
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

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