The Registry of Toxic Effects of Chemical Substances

Silicic acid (H2SiO3) , disodium salt

RTECS #: VV9275000

CAS #: 6834-92-0

UPDATE: August 2003 MW: 122.07 MF: O3Si•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Crystamet
  2. Disodium metasilicate
  3. Disodium monosilicate
  4. Metso 20
  5. Metso beads 2048
  6. Metso beads, drymet
  7. Metso pentabead 20
  1. Orthosil
  2. B - W
  3. Sodium silicate
  4. Sodium metasilicate
  5. Sodium metasilicate, anhydrous
  6. Water glass


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
guinea pig 		250 mg/24 hour moderate TXAPA9 31,481,1975
skin
human 		250 mg/24 hour severe TXAPA9 31,481,1975
skin
rabbit 		250 mg/24 hour severe TXAPA9 31,481,1975


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratesticular
rat 		lowest published toxic dose: 9,766 µg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964
oral
rat 		lowest published toxic dose: 15 gm/kg (14 week male/14 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) 		JANSAG 36,271,1973
subcutaneous
rat 		lowest published toxic dose: 9,766 µg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
guinea pig 		lowest published lethal dose: 200 mg/kg N/R JAMAAP 111,1925,1938
oral
dog 		lowest published lethal dose: 250 mg/kg Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes 		FCTXAV 14,78,1976
oral
man 		lowest published toxic dose: 1 mL/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Hematuria

Gastrointestinal: Nausea or vomiting 		JJAMA* 17,55,1993
oral
mouse 		lethal dose (50 percent kill): 770 mg/kg Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Ulceration or bleeding from duodeum

Gastrointestinal: Ulceration or bleeding from small intestine 		TOLED5 31(Suppl),44,1986
oral
pig 		lowest published lethal dose: 250 mg/kg N/R FCTXAV 14,78,1976
oral
rat 		lethal dose (50 percent kill): 1,153 mg/kg Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Ulceration or bleeding from duodeum

Gastrointestinal: Ulceration or bleeding from small intestine 		TOLED5 31(Suppl),44,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 224 mg/kg/4 week- continuous Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Urine volume increased 		PNASA6 65,872,1970


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
NTIS** PB-287-766


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,334,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80079;
Number of Industries 300;
Total Number of Facilities 97,326;
Number of Occupations 154;
Total Number of Employees Exposed 838,120
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80079;
Number of Industries 281;
Total Number of Facilities 59,514;
Number of Occupations 164;
Total Number of Employees Exposed 971,688;
Total Number of Female Employees Exposed 275,947


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as source of soluble SILICA, detergent builder, laminating adhesives, refractory binder
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942-
JJAMA* Japanese Journal of Acute Medicine. (Nihon Kyukyu Igakkai Jun Kikanshi, Herusu Shuppan, 2-3 Nakano 2-chome, Nakanoku Tokyo 164, Japan) V.1- 196(?)-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as source of soluble SILICA, detergent builder, laminating adhesives, refractory binder

Top 50 chemical production: 1.80 billions lbs in 1992, 1.74 billions in 1991

NIOSH PROFILE (SILICON AND ITS COMPOUNDS), SRI, 2/77

RTECS Compound Description:
   Reproductive Effector
   Human Data
   Primary Irritant

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