The Registry of Toxic Effects of Chemical Substances

Silicate (2 - ) , hexafluoro - , disodium

RTECS #: VV8410000

CAS #: 16893-85-9

UPDATE: November 2003 MW: 188.07 MF: F6Si•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Destruxol applex
  2. Disodium hexafluorosilicate (2 - )
  3. Disodium silicofluoride
  4. Ens - zem weevil bait
  5. ENT 1,501
  6. Fluosilicate de sodium
  7. Ortho earwig bait
  8. Ortho weevil bait
  9. Prodan
  10. Safsan
  1. Salufer
  2. Natriumsilicofluorid (German)
  3. PSC Co - Op weevil bait
  4. Silicon sodium fluoride
  5. Sodium fluosilicate
  6. Sodium hexafluorosilicate
  7. Sodium hexafluosilicate
  8. Sodium silicofluoride
  9. Sodium silicon fluoride
  10. Super prodan


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe FCTOD7 20,573,1982
eye
rabbit 		100 mg/4S rinse severe FCTOD7 20,573,1982
skin
rabbit 		500 mg mild FCTOD7 20,563,1982


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): 70 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Ataxia

Behavioral: Muscle contraction or spasticity 		GISAAA 53(11),80,1988
oral
rat 		lethal dose (50 percent kill): 125 mg/kg N/R ARSIM* 20,21,1966
oral
rabbit 		lethal dose (50 percent kill): 125 mg/kg N/R FMCHA2 -,C268,1991
subcutaneous
frog 		lowest published lethal dose: 448 mg/kg N/R CRSBAW 124,133,1937
subcutaneous
rat 		lowest published lethal dose: 70 mg/kg Liver: Fatty liver degeneration

Liver: Other changes

Kidney, Ureter, and Bladder: Changes primarily in glomeruli 		JPETAB 39,246,1930
unreported route
human 		lowest published lethal dose: 5.7 mg/kg N/R VCVN5* -,359,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 248 mg/kg/30 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Musculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		GISAAA 53(11),80,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 27,237,1982
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 27,237,1982
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,208,1987
TOXICOLOGY REVIEW
AMSSAQ 400,5,1963


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,317,1998
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 41,50-204.50,1994


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUORIDES, INORGANIC-air 10 hour time-weighted average 2.5 mg(F)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84233;
Number of Industries 43;
Total Number of Facilities 3,995;
Number of Occupations 50;
Total Number of Employees Exposed 20,064
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84233;
Number of Industries 74;
Total Number of Facilities 8,057;
Number of Occupations 60;
Total Number of Employees Exposed 79,556;
Total Number of Female Employees Exposed 22,185


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate in production of synthetic cyrolite and as a drinking-water additive
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AMSSAQ Acta Medica Scandinavica, Supplement. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) No.1-730, 1921-88.
ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as an intermediate in production of synthetic cyrolite and as a drinking-water additive

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Primary Irritant

ALT CAS #: 1310-02-7
ALT CAS #: 39413-34-8
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