The Registry of Toxic Effects of Chemical Substances

Silica, crystalline - tridymite

RTECS #: VV7335000

CAS #: 15468-32-3

UPDATE: May 2005 MW: 60.09 MF: O2Si


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Christensenite
  2. Silica, crystalline - tridymite (ACGIH:OSHA)
  3. Tridimite (French)
  1. Tridymite
  2. Tridymite 118
  3. alpha - Tridymite


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sister chromatid exchange human lymphocyte 13,514 µg/kg BJIMAG 47,110,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intrapleural
rat 		lowest published toxic dose: 100 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease 		BJCAAI 41,908,1980
intratracheal
mouse 		lowest published toxic dose: 400 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		PAACA3 15,6,1974


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 16 million particles per cubic foot/8 hour/17.9 year- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea 		NTIS** PB246-697
intratracheal
rat 		lowest published lethal dose: 200 mg/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) BJIMAG 10,9,1953


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (R) DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 42,39,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 42,39,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 68,41,1997
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMSUDL 7,341,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - respirable dust in air time-weighted average 10 mg/m3/2(% resp. SiO2+2) DTLWS* 3,33,1973
Mine Safety and Health Administration (MSHA) STANDARD - total dust in air time-weighted average 30 mg/m3/2(% resp. SiO2+3) DTLWS* 3,33,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3/(% resp SiO2+2) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3/(% resp SiO2+2) CFRGBR 29,1926.55,1994
Occupational Exposure Limit - AUSTRIA MAK 0.15 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 mg/m3, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 10/(2X+2), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.15 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.15 mg/m3 (total dust), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg/m3 (resp. dust), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.075 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.15 mg/m3, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.23 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.05 mg/m3 (R)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 mg/m3 (R)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SILICA, crystalline tridymite-air Carcinogen;
10 hour time-weighted average 0.05 mg/m3 		NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 74617;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 1;
Total Number of Employees Exposed 2,042;
Total Number of Female Employees Exposed 351


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
NIOSH Analytical Method, 1994: Silica, crystalline, by XRD, 7500; by VIS, 7600; by IR, 7602
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID-125G


REFERENCES:

CODEN
REFERENCE
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-

Used as a feltering and insulating media and as a refactory material for furnace linings

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

ALT CAS #: 1317-94-8
ALT CAS #: 12414-70-9
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