The Registry of Toxic Effects of Chemical Substances

Silane, chlorotrimethyl -

RTECS #: VV2710000

CAS #: 75-77-4

UPDATE: October 1997 MW: 108.66 MF: C3H9ClSi


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Chlorotrimethylsilane
  2. Silane, trimethylchloro -
  3. Silicane, chlorotrimethyl -
  1. TL 1163
  2. Trimethyl chlorosilane
  3. Trimethylsilyl chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5 µL moderate ATDAEI 12,574,1993
skin
rabbit 		500 µL moderate ATDAEI 12,574,1993


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) ENMUDM 8(Suppl 7),1,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 1,000 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		JNCIAM 54,495,1975


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 100 mg/m3 N/R USKHAB 38,2173,1969
intraperitoneal
mouse 		lowest published lethal dose: 750 mg/kg Immunological Including Allergic: Decreased immune response StoGD# 27MAY1975
oral
rat 		lethal dose (50 percent kill): 5,660 µL/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes 		ATDAEI 12,574,1993
skin
rabbit 		lethal dose (50 percent kill): 1,780 µL/kg Behavioral: Altered sleep time (including change in righting reflex)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ATDAEI 12,574,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83272;
Number of Industries 3;
Total Number of Facilities 59;
Number of Occupations 4;
Total Number of Employees Exposed 200
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83272;
Number of Industries 2;
Total Number of Facilities 8;
Number of Occupations 15;
Total Number of Employees Exposed 1,876;
Total Number of Female Employees Exposed 20


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate in production of silicones
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
StoGD# Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975
USKHAB Uspekhi Khimii. Progress in Chemistry. For English translation, see RCRVAB. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1932-

Used as intermediate in production of silicones

NIOSH PROFILE (SILICON COMPOUNDS, ORGANIC), SRC, 12/79

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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