The Registry of Toxic Effects of Chemical Substances

Sebacic acid, dibutyl ester

RTECS #: VS1150000

CAS #: 109-43-3

UPDATE: June 2000 MW: 314.52 MF: C18H34O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Dibutylester kyseliny sebakove (Czech)
  2. Dibutyl sebacate
  3. Di - n - butyl sebacate
  4. Polycizer DBS
  5. Bis (n - butyl) sebacate
  1. Decanedioic acid, dibutyl ester
  2. Kodaflex DBS
  3. Monoplex DBS
  4. PX 404
  5. Staflex DBS


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 418 gm/kg (10 week male/10 day prior to copulation) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) AMIHBC 7,310,1953


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration : >5,400 µg/m3/2 hour N/R GISAAA 55(6),86,1990
inhalation
rat 		lethal concentration : >5,400 µg/m3/4 hour N/R GISAAA 55(6),86,1990
intraperitoneal
mouse 		lethal dose (50 percent kill): 14,700 µL/kg N/R JBMRBG 8,11,1974
oral
mouse 		lethal dose (50 percent kill): 19,500 mg/kg Lung, Thorax, or Respiration: Other changes GISAAA 55(6),86,1990
oral
rat 		lethal dose (50 percent kill): 14,870 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Liver: Liver function tests impaired 		STGNBT -,69,1999


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 66 gm/kg/30 day- intermittent Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		STGNBT -,69,1999
unreported route
rabbit 		lowest published toxic dose: 50,400 mg/kg/12 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		STGNBT -,69,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84499;
Number of Industries 4;
Total Number of Facilities 67;
Number of Occupations 10;
Total Number of Employees Exposed 2,492
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84499;
Number of Industries 4;
Total Number of Facilities 400;
Number of Occupations 5;
Total Number of Employees Exposed 4,856;
Total Number of Female Employees Exposed 2,157


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an agent in production of food packing materials
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1967-
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999

Used as an agent in production of food packing materials

RTECS Compound Description:
   Reproductive Effector

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