The Registry of Toxic Effects of Chemical Substances

Salicylic acid

RTECS #: VO0525000

CAS #: 69-72-7

UPDATE: May 2005 MW: 138.13 MF: C7H6O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acido o - idrossibenzoico (Italian)
  2. Acido salicilico (Italian)
  3. Orthohydroxybenzoic acid
  4. Retarder W
  5. Benzoic acid, 2 - hydroxy -
  6. o - Hydroxybenzoic acid
  7. 2 - Hydroxybenzoic acid
  1. Keralyt
  2. Kyselina 2 - hydroxybenzoova (Czech)
  3. Kyselina salicylova (Czech)
  4. SA
  5. SAX
  6. Verrugon


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe BIOFX* 21-3/1971
skin
rabbit 		500 mg/24 hour mild BIOFX* 21-3/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition oral
mouse 		100 mg/kg MUREAV 46,305,1977
DNA repair Bacillus subtilis 5 mg/disc JNUDAT 34,183,1992
mutation in microorganisms Salmonella typhimurium 100 µg/disc (+enzymatic activation step) JNUDAT 34,183,1992
mutation in microorganisms Saccharomyes cerevisiae 1 mmol/L/3 hour (-enzymatic activation step) MUREAV 60,291,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 1 gm/kg (17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		APTOA6 35,107,1974
oral
mouse 		lowest published toxic dose: 500 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system APTOA6 35,107,1974
oral
rat 		lowest published toxic dose: 40 mg/kg (20-21 day pregnant) Reproductive: Maternal effects: Parturition PRGLBA 4,93,1973
oral
rat 		lowest published toxic dose: 1,050 mg/kg (8-14 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		SEIJBO 13,73,1973
oral
rat 		lowest published toxic dose: 1,050 mg/kg (8-14 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		SEIJBO 13,73,1973
oral
rat 		lowest published toxic dose: 700 mg/kg (8-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		SKEZAP 14,549,1973
oral
rat 		lowest published toxic dose: 350 mg/kg (8-14 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) SKEZAP 14,549,1973
subcutaneous
rat 		lowest published toxic dose: 380 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities 		BCPCA6 22,407,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): >300 mg/m3 N/R GISAAA 57(7-8),31,1992
inhalation
rat 		lethal concentration (50 percent kill): >900 mg/m3/1 hour N/R BIOFX* 21-3/1971
intraperitoneal
mouse 		lethal dose (50 percent kill): 300 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression 		GNRIDX 3,675,1969
intraperitoneal
rat 		lethal dose (50 percent kill): 157 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Nutritional and Gross Metabolic: Body temperature decrease 		GISAAA 57(7-8),31,1992
intravenous
mouse 		lethal dose (50 percent kill): 184 mg/kg Behavioral: Convulsions or effect on seizure threshold YKKZAJ 91,550,1971
oral
cat 		lethal dose (50 percent kill): 400 mg/kg N/R HBTXAC 5,148,1959
oral
mouse 		lethal dose (50 percent kill): 480 mg/kg N/R HBTXAC 5,148,1959
oral
rat 		lethal dose (50 percent kill): 891 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness 		BIOFX* 21-3/1971
oral
rabbit 		lethal dose (50 percent kill): 1,300 mg/kg N/R NIIRDN 6,291,1982
subcutaneous
mouse 		lethal dose (60 percent kill): 520 mg/kg Cardiac: Change in rate

Behavioral: Muscle weakness 		AIPTAK 38,9,1930
subcutaneous
rabbit 		lowest published lethal dose: 6 gm/kg N/R HBAMAK 4,1392,1935
skin
man 		lowest published toxic dose: 57 mg/kg Ear: Tinnitus JAMAAP 244,660,1980
skin
rat 		lethal dose (50 percent kill): >2 gm/kg Liver: Other changes

Skin and Appendages: Other: Hair 		ATDAEI 15(Suppl 1),S81,1996
skin
rabbit 		lethal dose (50 percent kill): >10 gm/kg N/R BIOFX* 21-3/1971
skin
woman 		lowest published toxic dose: 111 mg/kg/10 day- intermittent Ear: Change in acuity

Cardiac: Pulse rate increased without fall in BP

Nutritional and Gross Metabolic: Body temperature increase 		PGMJAO 70,146,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
AIPTAK 34,173,1928
TOXICOLOGY REVIEW
TOLED5 144,383,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,334,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 67680;
Number of Industries 39;
Total Number of Facilities 6,955;
Number of Occupations 57;
Total Number of Employees Exposed 61,410
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 67680;
Number of Industries 40;
Total Number of Facilities 2,133;
Number of Occupations 50;
Total Number of Employees Exposed 51,922;
Total Number of Female Employees Exposed 20,096


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a topical keratolytic agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?).
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JNUDAT Journal of Nihon University School of Dentistry. (Nihon University School of Dentistry, 1-8-13 Surugadai, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1958-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925-
PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7.
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

Used as a topical keratolytic agent

FDA-over the counter drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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