The Registry of Toxic Effects of Chemical Substances

Salicylic acid, methyl ester

RTECS #: VO4725000

CAS #: 119-36-8

UPDATE: February 2005 MW: 152.16 MF: C8H8O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. o - Anisic acid
  2. Exagien
  3. Flucarmit
  4. Oil of wintergreen
  5. Benzoic acid, 2 - hydroxy - , methyl ester
  6. Betula
  7. Betula oil
  8. Gaultheria oil, artificial
  9. Gaultheria oil
  10. o - Hydroxybenzoic acid, methyl ester
  1. 2 - Hydroxybenzoic acid methyl ester
  2. Methylester kyseliny salicylove (Czech)
  3. Methyl o - hydroxybenzoate
  4. Methyl salicylate
  5. Natural wintergreen oil
  6. Synthetic wintergreen oil
  7. Teaberry oil
  8. Wintergreen oil
  9. Wintergreen oil, synthetic


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
guinea pig 		1,00% severe FCTXAV 16,821,1978
eye
rabbit 		500 mg/24 hour mild 85JCAE -,668,1986
skin
guinea pig 		1,00% severe FCTXAV 16,821,1978
skin
rabbit 		500 mg/24 hour moderate FCTXAV 16,821,1978


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 100 µg/disc (+enzymatic activation step) JNUDAT 34,183,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 400 mg/kg (12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FAATDF 11,381,1988
intraperitoneal
rat 		lowest published toxic dose: 500 mg/kg (11-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system 		FAATDF 11,381,1988
oral
hamster 		lowest published toxic dose: 1,750 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TJADAB 28,421,1983
oral
rat 		lowest published toxic dose: 36,450 mg/kg (multigenerations) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) 		TXAPA9 18,755,1971
subcutaneous
rat 		lowest published toxic dose: 500 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Central nervous system 		AJPAA4 35,315,1959
subcutaneous
rat 		lowest published toxic dose: 500 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		AJPAA4 35,315,1959
skin
hamster 		lowest published toxic dose: 5,250 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TJADAB 28,421,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 18 mg/m3 Behavioral: Change in psychophysiological tests GISAAA 1,4,1994
oral
child 		lowest published lethal dose: 228 mg/kg Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting 		AJDCAI 69,37,1945
oral
child 		lowest published lethal dose: 700 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: General anesthetic

Lung, Thorax, or Respiration: Dyspnea 		ADCHAK 28,475,1953
oral
dog 		lethal dose (50 percent kill): 2,100 mg/kg Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting 		FCTXAV 16,821,1978
oral
guinea pig 		lethal dose (50 percent kill): 700 mg/kg N/R 14CYAT 2,1897,1963
oral
human 		lowest published lethal dose: 506 mg/kg N/R 85KYAH 11,961,1989
oral
infant 		lowest published lethal dose: 1,480 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting 		AJMSA9 193,772,1937
oral
man 		lowest published lethal dose: 101 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting 		AJMSA9 193,772,1937
oral
man 		lowest published lethal dose: 1,329 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Blood: Hemorrhage 		CTOXAO 6,189,1973
oral
mouse 		lethal dose (50 percent kill): 1,110 mg/kg N/R JPETAB 132,207,1961
oral
rat 		lethal dose (50 percent kill): 887 mg/kg Behavioral: Somnolence (general depressed activity) FCTXAV 2,327,1964
oral
rat 		lethal dose (50 percent kill): 1,220 mg/kg N/R GISAAA 1,4,1994
oral
rat 		lowest published toxic dose: 122 mg/kg Behavioral: Change in psychophysiological tests

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GISAAA 1,4,1994
oral
rabbit 		lethal dose (50 percent kill): 1,300 mg/kg N/R FCTXAV 16,821,1978
oral
woman 		lowest published lethal dose: 355 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting 		AJMSA9 193,772,1937
subcutaneous
dog 		lowest published lethal dose: 2,250 mg/kg N/R FCTXAV 16,821,1978
subcutaneous
guinea pig 		lowest published lethal dose: 1,500 mg/kg N/R FAONAU 44A,63,1967
subcutaneous
rabbit 		lowest published lethal dose: 4,250 mg/kg N/R FCTXAV 16,821,1978
unreported route
man 		lowest published lethal dose: 522 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 40 mg/m3/4 week- intermittent Immunological Including Allergic: Anaphylaxis (multiple organ involvement) GISAAA 1,4,1994
inhalation
mouse 		lowest published toxic concentration: 40 mg/m3/4 week- intermittent Immunological Including Allergic: Decreased immune response GISAAA 1,4,1994
inhalation
rat 		lowest published toxic concentration: 40 mg/m3/4 hour/17 week- intermittent Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		GISAAA 57(7-8),28,1992
inhalation
rat 		lowest published toxic concentration: 8 mg/m3/4 hour/16 week- intermittent Behavioral: Change in psychophysiological tests

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases 		GISAAA 1,4,1994
oral
dog 		lowest published toxic dose: 40,800 mg/kg/59 day- intermittent Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 5,576,1963
oral
dog 		lowest published toxic dose: 93,600 mg/kg/2 year- intermittent Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 5,576,1963
oral
dog 		lowest published toxic dose: 35 gm/kg/10 week- intermittent Liver: Fatty liver degeneration FAONAU 44A,1,1967
oral
rat 		lowest published toxic dose: 71,400 mg/kg/17 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 5,576,1963
oral
rat 		lowest published toxic dose: 546 gm/kg/2 year- continuous Cardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 5,576,1963
oral
rat 		lowest published toxic dose: 85,200 mg/kg/10 week- continuous Musculoskeletal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 5,576,1963
skin
rat 		lowest published toxic dose: 281.1 mg/kg/3 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight TXCYAC 117,229,1997
skin
rabbit 		lowest published toxic dose: 330 gm/kg/90 day- intermittent Gastrointestinal: Changes in structure or function of exocrine pancreas

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 5,576,1963


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
DICPBB 9,350,1975
TOXICOLOGY REVIEW
CLCHAU 19,361,1973
TOXICOLOGY REVIEW
ARVPAX 5,447,1965
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965
TOXICOLOGY REVIEW
EVHPAZ 15,121,1976
TOXICOLOGY REVIEW
FAATDF 13,747,1989
TOXICOLOGY REVIEW
TOLED5 140-141,239,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,334,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 48320;
Number of Industries 138;
Total Number of Facilities 15,668;
Number of Occupations 80;
Total Number of Employees Exposed 105,490
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 48320;
Number of Industries 193;
Total Number of Facilities 30,724;
Number of Occupations 134;
Total Number of Employees Exposed 454,822;
Total Number of Female Employees Exposed 134,722


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a topical analgesic
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB 560B, Kennebunkport, ME 04046) V.1- 1926-
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960-
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) New series: V.1- 1841-
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI.
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JNUDAT Journal of Nihon University School of Dentistry. (Nihon University School of Dentistry, 1-8-13 Surugadai, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1958-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a topical analgesic

FDA-over the counter drug

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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