The Registry of Toxic Effects of Chemical Substances
Rosin |
UPDATE: November 2004 | MW: N/R | MF: N/R |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
N/R | N/R | N/R | N/R |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lethal concentration (50 percent kill): 110 mg/m3 |
Behavioral: Somnolence (general depressed activity) Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Respiratory depression | VCVPS* -,294,1998 |
oral mouse | lethal dose (50 percent kill): 2.2 mg/kg |
Behavioral: Somnolence (general depressed activity) Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Respiratory depression | VCVPS* -,294,1998 |
oral rat | lethal dose (50 percent kill): 3.0 mg/kg |
Brain and Coverings: Other degenerative changes Liver: Other changes Biochemical: Metabolism (intermediary): Other | VCVPS* -,294,1998 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral rat | lowest published toxic dose: 175 gm/kg/50 day- intermittent |
Lung, Thorax, or Respiration: Dyspnea Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Fatty liver degeneration | VCVPS* -,294,1998 |
oral rabbit | lowest published toxic dose: 455 gm/kg/13 week- intermittent |
Liver: Other changes Blood: Thrombocytopenia Nutritional and Gross Metabolic: Changes in: K | VCVPS* -,294,1998 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | reduce to as low as possible | DTLVS* TLV/BEI,1999 |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average L (sen) | DTLVS* TLV/BEI,2003 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 0.1 mg/m3, 2003 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: X2732![]() Number of Industries 1; Total Number of Facilities 511; Number of Occupations 1; Total Number of Employees Exposed 511 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: X6806![]() Number of Industries 9; Total Number of Facilities 758; Number of Occupations 14; Total Number of Employees Exposed 8,324; Total Number of Female Employees Exposed 2,339 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 80164![]() Number of Industries 199; Total Number of Facilities 27,401; Number of Occupations 133; Total Number of Employees Exposed 566,016; Total Number of Female Employees Exposed 212,612 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY |
REFERENCES: | |
CODEN |
REFERENCE |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
VCVPS* | "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998. |