The Registry of Toxic Effects of Chemical Substances

Resorcinol, diglycidyl -

RTECS #: VH1050000

CAS #: 101-90-6

UPDATE: May 2005 MW: 222.26 MF: C12H14O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Araldite ERE 1359
  2. Diglycidyl ether of resorcinol
  3. 1,3 - Diglycidyloxybenzene
  4. Diglycidyl resorcinol ether
  5. Oxirane, 2,2' - (1,3 - phenylenebis (oxymethylene) ) bis -
  6. 2,2' - (1,3 - Phenylenebis (oxymethylene) ) bisoxirane
  7. Resorcinol bis (2,3 - epoxypropyl) ether
  8. m - Bis (2,3 - epoxypropoxy) benzene
  1. 1,3 - Bis (2,3 - epoxypropoxy) benzene
  2. meta - Bis (glycidyloxy) benzene
  3. ERE 1359
  4. NCI - C54966
  5. RDGE
  6. Resorcinol diglycidyl ether
  7. Resorcinyl diglycidyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate AMIHAB 17,129,1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 8 mg/L MUREAV 135,159,1984
mutation in microorganisms Salmonella typhimurium 33 µg/plate (+/-enzymatic activation step) MUREAV 172,105,1986
mutation in mammalian somatic cells mouse lymphocyte 100 µg/L SCIEAS 236,933,1987
sister chromatid exchange hamster ovary 50 µg/L SCIEAS 236,933,1987
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		5 pph ENMUDM 7,325,1985
heritable translocation test oral
Drosophila melanogaster 		5 pph ENMUDM 7,325,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 25,750 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTPTR* NTP-TR-257,1986
oral
mouse 		toxic dose : 51,500 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease 		NTPTR* NTP-TR-257,1986
oral
mouse 		toxic dose : 25,750 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		FCTOD7 28,723,1990
oral
mouse 		lowest published toxic dose: 25,750 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB87-146734/AS
oral
rat 		lowest published toxic dose: 6,180 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTPTR* NTP-TR-257,1986
oral
rat 		toxic dose : 12,875 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		FCTOD7 28,723,1990
oral
rat 		lowest published toxic dose: 12,875 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB87-146734/AS
unreported route
mouse 		lowest published toxic dose: 6,700 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		RARSAM 3,193,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 243 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Peritonitis 		AMIHAB 17,129,1958
intraperitoneal
rat 		lethal dose (50 percent kill): 178 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Peritonitis 		AMIHAB 17,129,1958
oral
mouse 		lethal dose (50 percent kill): 980 mg/kg Behavioral: Somnolence (general depressed activity) AMIHAB 17,129,1958
oral
rat 		lethal dose (50 percent kill): 2,570 mg/kg Gastrointestinal: Ulceration or bleeding from duodeum AMIHAB 17,129,1958
oral
rabbit 		lethal dose (50 percent kill): 1,240 mg/kg Behavioral: Somnolence (general depressed activity) AMIHAB 17,129,1958


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 10,500 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-257,1986
oral
mouse 		lowest published toxic dose: 26 gm/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-257,1986
oral
rat 		lowest published toxic dose: 5,320 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-257,1986
oral
rat 		lowest published toxic dose: 13 gm/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-257,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 36,181,1985
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,1417,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 36,181,1985
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1417,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,1417,1999
TOXICOLOGY REVIEW
MUREAV 567,347,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83725;
Number of Industries 4;
Total Number of Facilities 193;
Number of Occupations 8;
Total Number of Employees Exposed 2,994
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83725;
Number of Industries 5;
Total Number of Facilities 28;
Number of Occupations 7;
Total Number of Employees Exposed 1,856;
Total Number of Female Employees Exposed 222


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a liquid epoxy resin and as a reactive diluent in the production of epoxy resins
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued.
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-

Used as a liquid epoxy resin and as a reactive diluent in the production of epoxy resins

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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