The Registry of Toxic Effects of Chemical Substances

Resorcinol

RTECS #: VG9625000

CAS #: 108-46-3

UPDATE: February 2005 MW: 110.12 MF: C6H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. C.I. 76505
  2. C.I. Developer 4
  3. C.I. Oxidation Base 31
  4. m - Dihydroxybenzene
  5. 1,3 - Dihydroxybenzene
  6. m - Dioxybenzene
  7. Nako TGG
  8. Pelagol Grey RS
  9. Pelagol RS
  10. Phenol, m - hydroxy -
  11. Resorcin
  12. Resorcine
  13. Benzene, m - dihydroxy -
  14. m - Benzenediol
  15. 1,3 - Benzenediol
  1. Developer O
  2. Developer R
  3. Developer RS
  4. Durafur developer G
  5. Fouramine RS
  6. Fourrine 79
  7. Fourrine EW
  8. m - Hydroquinone
  9. 3 - Hydroxycyclohexadien - 1 - one
  10. m - Hydroxyphenol
  11. 3 - Hydroxyphenol
  12. NCI - C05970
  13. RCRA waste number U201
  14. Resorcinol (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe BIOFX* 11-4/1970
skin
rabbit 		500 mg severe IHFCAY 6,1,1967
skin
rabbit 		20 mg/24 hour moderate 85JCAE -,234,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 1,600 mg/L CALEDQ 14,251,1981
cytogenetic analysis human lymphocyte 80 mg/L ARZNAD 32,533,1982
cytogenetic analysis human other cell types 40 mg/L ARZNAD 32,533,1982
cytogenetic analysis human lymphocyte 0.2 pph VCVGK* -,227,1994
cytogenetic analysis oral
mouse 		0.5 ppb EMMUEG 39,69,2002
cytogenetic analysis oral
rat 		0.5 ppb EMMUEG 39,69,2002
DNA damage rat liver 10 mmol/L CALEDQ 63,47,1992
mutation in microorganisms Salmonella typhimurium 20 µmol/plate (+/-enzymatic activation step) MUREAV 90,91,1981
gene conversion and mitotic recombination Saccharomyes cerevisiae 1 gm/L MUREAV 135,109,1984
specific locus test oral
mouse 		0.5 ppb EMMUEG 39,69,2002
specific locus test oral
rat 		0.5 ppb EMMUEG 39,69,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 4,800 mg/kg/12 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		CNREA8 19,413,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 160 mg/m3/1 hour N/R BIOFX* 11-4/1970
intraperitoneal
mouse 		lethal dose (50 percent kill): 215 mg/kg N/R BEXBAN 61,291,1966
intravenous
dog 		lowest published lethal dose: 700 mg/kg N/R VCVGK* -,227,1994
oral
human 		lowest published lethal dose: 29 mg/kg N/R 34ZIAG -,519,1969
oral
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R JJTOEX 4,105,1991
oral
rat 		lethal dose (50 percent kill): 301 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands

Lung, Thorax, or Respiration: Dyspnea 		BIOFX* 11-4/1970
oral
rat 		lethal dose (50 percent kill): 301 mg/kg N/R VCVGK* -,227,1994
parenteral
frog 		lowest published lethal dose: 270 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes 		AEPPAE 166,437,1932
subcutaneous
cat 		lowest published lethal dose: 110 mg/kg Behavioral: Convulsions or effect on seizure threshold

Blood: Methemoglobinemia- Carboxhemoglobinemia 		AEXPBL 72,241,1913
subcutaneous
cat 		lowest published lethal dose: 110 mg/kg N/R VCVGK* -,227,1994
subcutaneous
guinea pig 		lowest published lethal dose: 400 mg/kg Behavioral: Excitement

Behavioral: Tetany

Behavioral: Coma 		RMSRA6 15,561,1895
subcutaneous
guinea pig 		lowest published lethal dose: 400 mg/kg N/R VCVGK* -,227,1994
subcutaneous
mouse 		lethal dose (50 percent kill): 213 mg/kg N/R ZGIMAL 2,333,1947
subcutaneous
rat 		lowest published lethal dose: 400 mg/kg Behavioral: Excitement

Behavioral: Tetany

Behavioral: Coma 		RMSRA6 15,561,1895
subcutaneous
rat 		lowest published lethal dose: 400 mg/kg N/R VCVGK* -,227,1994
skin
mouse 		lowest published lethal dose: 340 mg/kg N/R VCVGK* -,226,1994
skin
rabbit 		lethal dose (50 percent kill): 3,360 mg/kg Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AIHAAP 37,596,1976
skin
rabbit 		lethal dose (50 percent kill): 3,360 mg/kg N/R VCVGK* -,227,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 3,600 mg/kg/17 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-403,1992
oral
mouse 		lowest published toxic dose: 27,300 mg/kg/13 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-403,1992
oral
mouse 		lowest published toxic dose: 115,875 mg/kg/103 week- intermittent Skin and Appendages: Tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB93-126381
oral
rat 		lowest published toxic dose: 5,400 mg/kg/17 day- intermittent Endocrine: Changes in thymus weight NTPTR* NTP-TR-403,1992
oral
rat 		lowest published toxic dose: 8,450 mg/kg/13 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight 		NTPTR* NTP-TR-403,1992
oral
rat 		lowest published toxic dose: 504 mg/kg/28 day- continuous Endocrine: Changes in adrenal weight BIOFX* 11-4/1970
oral
rat 		lowest published toxic dose: 25,750 mg/kg/103 week- intermittent Skin and Appendages: Tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB93-126381


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm;short term exposure limit 20 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 20 ppm DTLVS* TLV/BEI,2002
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 15,155,1977
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 71,1119,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 15,155,1977
International Agency for Research on Cancer (IARC) Cancer Review Human No adequate Data IMEMDT 71,1119,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1119,1999
TOXICOLOGY REVIEW
MUREAV 47,75,1978
TOXICOLOGY REVIEW
JACTDZ 5(3),167,1986
TOXICOLOGY REVIEW
MUREAV 5432012003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (45 mg/m3), short term exposure limit 20 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 10 ppm (45 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (45 mg/m3), short term exposure limit 20 ppm, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (45 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (45 mg/m3), short term exposure limit 20 ppm (90 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 10 ppm (45 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 45 mg/m3, short term exposure limit 90 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 45 mg/m3, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 45 mg/m3, MAC(short term exposure limit) 90 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 10 ppm (45 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (45 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (46 mg/m3), short term exposure limit 20 ppm (92 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 20 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 20 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO RESORCINAL-air 10 hour time-weighted average 10 ppm;
short term exposure limit 20 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 67220;
Number of Industries 45;
Total Number of Facilities 4,488;
Number of Occupations 42;
Total Number of Employees Exposed 40,431
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 67220;
Number of Industries 30;
Total Number of Facilities 6,842;
Number of Occupations 43;
Total Number of Employees Exposed 100,792;
Total Number of Female Employees Exposed 56,465


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the production of RESORCINOL-FORMALDEHYDE adhesives, or as an intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis Studies (gavagae);no evidence:mouse,rat NTPTR* NTP-TR-403,1992
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat
NTP Carcinogenesis studies; test completed (peer review), October 2000


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956-
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
ZGIMAL Zeitschrift fuer die Gesamte Innere Medizin und Ihre Grenzgebiete. (Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1946-

Used in the production of RESORCINOL-FORMALDEHYDE adhesives, or as an intermediate

NIOSH PROFILE (HAIRDRESSING and BARBERS), SRC, 6/80

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Human Data
   Primary Irritant

 Click Here for Additional Information about RTECS